Now showing items 1-20 of 5563

    • Bioactivity and mechanism of action of resveratrol, a polyhenolic phytoalexin, in sickle cell disease

      Agyekum, Davies G.; Medical College of Georgia (Augusta University, 2013-07)
    • Physicians' perceived incentives for association with nurse practitioners in the delivery of primary care

      Adinaro, Denise; School of Nursing (Augusta University, 1980-08)
      The purpose of this study was to identify those factors which physicians , currently associated with nurse practitioners, perceive as incentives in their motivation to associate with these nurse practitioners in providing primary care. A mail survey was sent to nurse practitioners and their associate physicians throughout the State of Georgia, with two follow-up postcard mailings. Data were collected for a 4 week period and a 30.46 return was obtained. A mean ranking of the identified incentives was performed. Two major categories of incentives were identified . To increase the quality of care was considered to be most important and to expand the services offered in general was rated second as incentives for physician association with nurse practitioners.
    • Supplemental Data and Material for Assessing the Health Information Seeking Behaviors and Needs of Nurses in Skilled Nursing Facilities

      Kouame, Gail; Yang, Frances; Hendren, Steph; University Libraries; Georgia War Veterans Nursing Home (2021-07-14)
    • Studies on calcium transport of the sarcoplasmic reticulum in skinned cardiac muscle

      Zhu, Yu; Department of Physiology and Endocrinology (Augusta University, 1990-11)
    • Angiogenesis-associated gene expression changes in surgical skin flaps of diabetic rats

      Zhou, Miao Xian (Cindy); Medical College of Georgia (Augusta University, 2010-07)
    • Aquaporin 3 in keratinocyte differentiation

      Zhan, Xiangjian; Medical College of Georgia (Augusta University, 2003-08)
      Aquaporin 3 (AQP3) is a channel that transports both water and glycerol. AQP3- null mutant mice exhibit skin defects, including impairment of water holding capacity, barrier recovery and wound healing and decreased glycerol content. We hypothesized that AQP3 is involved in the regulation ofkeratinocyte proliferation and differentiation and this regulation is mediated, at least in part, by the functional interaction between AQP3 and phospholipase D (PLD). Here we demonstrate that AQP3 expression was down-regulated at the transcriptional level and glycerol uptake was reduced when primary mouse keratinocytes were induced to differentiate. In co-transfection experiments, we found that AQP3 decreased the promoter activity of keratin 5, a keratinocyte proliferation marker, but increased the promoter activity of keratin 10 and involucrin, an early and intermediate keratinocyte differentiation marker respectively. These results suggest that AQP3 is a regulator of early keratinocyte differentiation. In further investigatjons to determine the sigualing function of AQP3 in regulating keratinocyte differentiation, we found using sucrose gradient centrifugation, irnmunoprecipitation analysis, confocal microscopy that AQP3 and PLD2 were colocalized in lipid rafts. In addition, we demonstrated that AQP3 could contribute to the synthesis of phosphatidylglycerol (PG) and that PLD2 was able to utilize glycerol as a substrate to synthesize PG. These data suggest that AQP3 transports glycerol for use as a physiological primary alcohol substrate for-adjacent PLD2 to generate PG. Our results, together with the reports that PG is an activator of protein kinases (PKqm and PKCe) and also contributes to protein-protein interactions in membranes, suggest that glycerol AQP3-PLD2-PG is a potential signaling pathway in regulating keratinocyte differentiation.
    • EFFECTS OF ATTENUATION OF a8 AND a6 INTEGRINS ON THE DEVELOPMENT OF CIDCKEN OPTIC TECTUM

      Zhang, Zhiqiang; Medical College of Georgia (Augusta University, 1997-05)
    • Characterization of leydig cell development in the rat testis

      Zhai, Juan; Medical College of Georgia (Augusta University, 1996-05)
    • CURS Connection Summer 2021

      Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2021-06)
      Table of Contents: First AU Undergraduates Earn a Distinction in Research; Summer Scholars Symposium; Time to Prep Fall Grant Proposals; Seeking CURS Ambassadors;
    • Teaching Matters July 2021

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2021-07-01)
      Table of Contents: A Note from the Vice Provost; Innovation Updates (Summer Instructional Development Series was a Success; Faculty Highlights (IPSO Features: Dr. Mostafa Khater, CURS 2021 Mentor of Excellence Award); Student Opportunities (On Campus Student Employment Fair, Pizza and a Plan with the Provost)
    • The effect of dentin desensitizers on the retention of full crowns cemented with a variety of luting/bonding agents

      Yim, Nantiya Harnkul; Department of Oral Biology (Augusta University, 1999-04-21)
    • Structural and functional aspects of organic cation transporters

      Wu, Xiang; Medical College of Georgia (Augusta University, 1999-07)
    • Confidence interval estimation for a binomial proportion when no successes are observed

      Wimmer, Courtney; Dias, James; Medical College of Georgia (Augusta University, 2009-04)
      Confidence interval estimation for a binomial proportion is a long debated topic, resulting in a wide range of exact and approximate methods. Many of these methods perform quite poorly when the number of observed successes in a sample of size n is zero. In this case, the main objective of the investigator is usually to obtain an upper bound, i.e., the upper limit of a onesided confidence interval. Traditional notions of expected interval length and coverage probability are not applicable in this situation. In this paper we use observed interval length and p-confidence to evaluate nine confidence interval methods for a binomial proportion. We also consider approximate sample sizes needed to achieve various upper bounds near the zero boundary. We show that many popular approximation methods perform poorly based on these criteria and conclude that the-exact method has superior performance in terms of interval length and p-confidence.
    • A Variable prenatal stress paradigm as a valid drug discovery platform for cognitive deficits associatied with neuropsychiatric disorders

      Wilson, Christina Ann; Medical College of Georgia (Augusta University, 2012-10)
      Cognitive dysfunction is now recognized to be central to the functional disability of several neuropsychiatric disorders. However, treatment options for the management of cognitive symptoms are limited and the development of novel therapeutics has been made difficult by the lack of appropriate animal models. It has been suggested that variable prenatal stress (PNS) in rodents might be an etiologically appropriate model for some components of schizophrenia. Thus, the overall goal of this dissertation project was to conduct a comprehensive behavioral study of the model to assess face validity, and to make a preliminary assessment of its construct and predictive validity. Our results indicate that exposure to PNS results in elevated corticosterone levels following exposure to acute stress, increased aggressive behaviors, as well as increased locomotor activity and stereotypic behaviors. Further, PNS rats had altered innate fear responses to predator odor as well as impaired fear extinction. Additionally, PNS in rats was associated with impairments of sustained attention, inhibitory response control, and recognition memory all of which could be attenuated by the norepinephrine reuptake inhibitor, atomoxetine. Collectivity, these data ,support the premise that PNS in rodents is a valid model system for studying some behavioral components of neuropsychiatric disorders as well as their treatment.
    • Interaction of ET-1 with vasoactive mediators

      WIlliams, Jan Michael; Medical College of Georgia (Augusta University, 2005-07)
    • Expression of connexin 43 in orthodontic tooth movement in a rat model

      Whitehead, James D., III; Department of Oral Biology (Augusta University, 1998-12)
    • Relationship between job satisfaction and intent to stay

      West, Myrion J.; School of Nursing (Augusta University, 1993-01)