Now showing items 1-20 of 5552

    • The effect of dentin desensitizers on the retention of full crowns cemented with a variety of luting/bonding agents

      Yim, Nantiya Harnkul; Department of Oral Biology (Augusta University, 1999-04-21)
    • Structural and functional aspects of organic cation transporters

      Wu, Xiang; Medical College of Georgia (Augusta University, 1999-07)
    • Confidence interval estimation for a binomial proportion when no successes are observed

      Wimmer, Courtney; Dias, James; Medical College of Georgia (Augusta University, 2009-04)
      Confidence interval estimation for a binomial proportion is a long debated topic, resulting in a wide range of exact and approximate methods. Many of these methods perform quite poorly when the number of observed successes in a sample of size n is zero. In this case, the main objective of the investigator is usually to obtain an upper bound, i.e., the upper limit of a onesided confidence interval. Traditional notions of expected interval length and coverage probability are not applicable in this situation. In this paper we use observed interval length and p-confidence to evaluate nine confidence interval methods for a binomial proportion. We also consider approximate sample sizes needed to achieve various upper bounds near the zero boundary. We show that many popular approximation methods perform poorly based on these criteria and conclude that the-exact method has superior performance in terms of interval length and p-confidence.
    • A Variable prenatal stress paradigm as a valid drug discovery platform for cognitive deficits associatied with neuropsychiatric disorders

      Wilson, Christina Ann; Medical College of Georgia (Augusta University, 2012-10)
      Cognitive dysfunction is now recognized to be central to the functional disability of several neuropsychiatric disorders. However, treatment options for the management of cognitive symptoms are limited and the development of novel therapeutics has been made difficult by the lack of appropriate animal models. It has been suggested that variable prenatal stress (PNS) in rodents might be an etiologically appropriate model for some components of schizophrenia. Thus, the overall goal of this dissertation project was to conduct a comprehensive behavioral study of the model to assess face validity, and to make a preliminary assessment of its construct and predictive validity. Our results indicate that exposure to PNS results in elevated corticosterone levels following exposure to acute stress, increased aggressive behaviors, as well as increased locomotor activity and stereotypic behaviors. Further, PNS rats had altered innate fear responses to predator odor as well as impaired fear extinction. Additionally, PNS in rats was associated with impairments of sustained attention, inhibitory response control, and recognition memory all of which could be attenuated by the norepinephrine reuptake inhibitor, atomoxetine. Collectivity, these data ,support the premise that PNS in rodents is a valid model system for studying some behavioral components of neuropsychiatric disorders as well as their treatment.
    • Interaction of ET-1 with vasoactive mediators

      WIlliams, Jan Michael; Medical College of Georgia (Augusta University, 2005-07)
    • Expression of connexin 43 in orthodontic tooth movement in a rat model

      Whitehead, James D., III; Department of Oral Biology (Augusta University, 1998-12)
    • Relationship between job satisfaction and intent to stay

      West, Myrion J.; School of Nursing (Augusta University, 1993-01)
    • Effect of structured patient education on level of hope in cancer patient

      Wells, Gayle; School of Nursing (Augusta University, 1991-02)
      The purpose of this study was to determine the effect of patient participation in a structured education program on the level of hope in cancer patients. The sample consisted of 34 adult subjects diagnosed with cancer within the last five years. The control group (n = 17) consisted of patients receiving care at a private physician's office. The treatment group (n = 17) consisted of participants in a structured education program (I Can Cope) at three sites in the southeastern United States. The Nowotny Hope Scale (NHS) (Nowotny, 1989) was used to measure.hope. A quasiexperimental non-equivalent control group pretest posttest design was utilized tb test the following hypothesis: Adult cancer patients who attend structured educational classes will score higher on a scale measuring hope than those patients who have not attended such a class. Both groups represent naturally occurring collectives and randomization was not possible. The groups were matched by type of cancer diagnosis. The analysis of covariance (ANCOVA) revealed no significant difference (p = .139) in the adjusted posttest scores of the two groups; therefore, the hypothesis was not supported. In this study, the level of hope for participants in a structured education program did not differ from the level of a similar group not attending such a program. However, in view of the attention given to the concept of hope as a factor in facing the diagnosis of cancer it is important that research efforts continue to be directed to the discovery of effective interventions to foster hope.
    • Mathematical modeling of the human dental arch and its usefulness in longitudinal analysis of treatment effects

      Weddle, Larry; Department of Oral Biology (Augusta University, 1999-11)
      In the practice of orthodontics, the shape of the dental arches is important in the planning and implementation of treatment. Many mathematical functions have been proposed for the characterization of arch form including catenary, p~lynomials, beta, conic sections, and cubic splines. The purpose of this study was to use linear and nonlinear least squares estimation to fit polynomial, catenary-like and beta-like curves to a longitudinal dataset and evaluate both the curve fits and the longitudinal information obtained. A longitudinal dataset was obtained from a private orthodontist. Dental casts of the upper and lower arches were made at three time points for each of 20 subjects: before treatment, immediately following treatment, and following a post-retention follow-up period of at least two years. Each cast and a calibration strip was scanned into a separate image computer file. Image analysis software was used to mark the (x,y) coordinates of buccal landmarks on each tooth from first molar to first molar. The (x, y) coordinates from each cast were collected into a central database for analysis. It was desired to use least squares for curve fitting due to its wide availability and well known properties. In order to use least squares, the casts were required to have consistent x-axis and y-axis orientation. This was done by orienting the x-axis parallel to the line connecting the centroids of the posterior teeth on the right and left sides of each cast. Eight functions were used in the curves fitting. The linear least squares method was used to fit polynomials of 2nd, 3rd, 4th, and 5th order. The nonlinear least squares method was used to fit a generalized 5-parameter beta function and generalized inverse catenary functions with 3, 4, and 5 parameters. Each of the eight functions was fit to each of the 120 dental casts in the study. Curve fits were examined for each function and each subject, arch, and time point. The 4th and 5th order polynomials, the generalized beta, and the 4-parameter and 5-parameter generalized inverse catenary functions fit well. For the 4th and 5th order polynomials, the R2 values ranged from xxx to xxx with acceptable visual fits. For the nonlinear models, the model sum of squares approximated the total sum of squares and the curves yielded good visual fits to the data points. Longitudinal analysis was done using Euclidean distance as the metric in the parameter space of each model. In order to assess the parameter metric in terms of physical measurements, the Euclidean distances in the parameter spaces were correlated with intercanine width, intermolar width, and molar-incisor distance. Consistent correlations were not identified though the curve fits were excellent. A comparison of arch form change between upper and lower arches was also done. Since the upper arches changed more, checking the ability of the parameter metrics of the various models to detect the change was of interest. and 3rd order polynomials, All of the models except 2nd and molar-incisor distance measures were capable of detecting the difference in change between the upper and lower arches (ANOVA p-values ~ 0.05). In summary, this study shows a successful method of orienting the casts for curve fitting by least squares. The models with at least 4 parameters generally fit well across the range of dental casts studied with the 5- parameter models slightly superior. The longitudinal analysis indicates that traditional linear measurements such as intercanine width may not adequately measure the multidimensional aspects of arch form change. The parameter space metrics were able to discriminate between upper and lower arch form changes.
    • Teaching Matters June 2021

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2021-06-01)
      Table of Contents: A Note from the Vice Provost; Innovation Updates (Self-Hugging: It's Not the Best Idea, Video-Assisted Debriefing, Spotlight on Data and Research Services, Career Readiness).
    • Teaching Matters May 2021

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2021-05-03)
      Table of Contents: A Note from the Vice Provost; Innovation Updates (USG Faculty Development Offers Summer Webinar Series, Boundless Teaching Award Winners Announced, University Libraries Celebrate National Library Week, Innovation Competition Winners Announced, Simulation Spotlight: Student Simulation Interns; Faculty and Staff Updates (Welcome Veronica Williams, Director of Academic Advisement, IPSO Features Dr. Ralf Lucas and Dr. Maritza Romero Lucus); Student Updates (Want to Help Get Your Students More Career Ready?, FYE/SYE Celebrates Half-Way There Event).
    • Enablers and barriers to the availability of services for HIV-infected persons /

      Walters, Metta L.; School of Nursing (Augusta University, 1990-12)
    • In vitro effects on fibroblast attachment following demineralization by citric acid compared to doxycycline HC1

      Jankowski, Eric P.; Department of Oral Biology & Pharmacology (Augusta University, 1993-05)
    • Ibuprofen Conjugates as Potential Anti-Inflammatory Drug Candidates

      Wade, Margaret; Department of Chemistry and Physics (Augusta University, 2021-05)
      Inflammation is a common immune response to harmful pathogens or damaged cells. Non-steroidal anti-inflammatory drugs (NAIDs) are commonly used to treat inflammation and pain. These drugs can also be used to treat inflammation due to diseases such as cancer, rheumatoid arthritis and Alzheimer’s disease. NSAIDs accomplish this through the inhibition of the cyclooxygenase (COX) enzyme systems. Selectivity for the inhibition of the COX-2 pathway is an aim in the development of NSAIDs. The COX-2 enzyme predominates at sites of inflammation and releases enzymes responsible for vasodilation. While the inhibition of the COX-1 pathway results in adverse side effects, such as gastric lesions and perforation. The current drug design process has focused on modifying existing NSAIDs, such as ibuprofen. In the current study, conjugates of ibuprofen were developed by incorporating triazole ring in the conjugated molecules through a ‘click’ chemistry approach. The anti-inflammatory properties of the conjugates were evaluated using the carrageenan-induced paw edema method.
    • Design and Synthesis of Metformin Derivatives as Anticancer Agents

      Thomas, Eyana; Department of Biological Sciences (Augusta University, 2021-05)
      Metformin is the first-line medication for type II diabetes. It initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that reduced cancer risk and improved clinical outcomes in diabetic patients taking Metformin. To uncover the anti-cancer mechanisms of Metformin, preclinical studies determined that Metformin impairs cellular metabolism and suppresses oncogenic signaling pathways. Recently, the anti-cancer potential of Metformin has gained increasing interest due to its inhibitory effects on cancer stem cells (CSCs), which are associated with tumor metastasis, drug resistance, and relapse. There is a need to optimize this drug to target a more general audience of non-diabetic cancer patients. Metformin has low bioavailability, a narrow absorption window, and extensive liver metabolism. Its oral administration is accompanied by gastrointestinal adverse effects, including nausea, abdominal pain, abdominal bloating, flatulence, dyspepsia, and anorexia, resulting in up to 50% of patients. We have synthesized metformin hybrid conjugates with aromatics compounds. Spectral studies characterized all the synthesized compounds. The hybrid conjugates showed improved LogP values, determined from computational analyses, over tenfold of Metformin's 0.15, suggesting that these candidates will show better bioavailability in the body.