Now showing items 1-20 of 5421

    • Access to Health Information: Outreach Efforts to Ronald McDonald House Augusta

      Bandy, Sandra L.; Brewster, Tamara; University Libraries (Georgia Regents University, 2015-10)
      Objective: The library seeks to improve the use of reliable electronic health information to fill this information need for an under-served population in crisis. In 2014, a new and larger Ronald McDonald House (RMH) opened in Augusta across a shared parking lot of the Robert B, Greenblatt, M.D. Library. Currently, there are no health information resources available in the house. The house staff/volunteers have shared that they have received questions about health information but are advised not to give medical advice. Methods: A computer designated for accessing health information and a small selection of printed materials has been made available within the RMH. The library is in position to train the RMH house staff/volunteers on consumer health resources and how to evaluate reliable web resources. This will allow them to promote authoritative health resources for families/caregivers of children who are receiving medical treatment at the Children’s Hospital of Georgia. A health information web page has been developed and is accessible through the RMH portal. This web page is also being used as a class outline for hands-on computer training sessions for RMH staff. Results: The results of the training within the past six months will be presented along with suggested improvements for the staff who are teaching caregivers how to access health information. Conclusion: Parents will do anything for their child, especially when they are sick. Often they turn to the internet searching for answers. The library recognized the potential to build a positive partnership with the community. Using our expertise to aid this under-served population will assist parents in finding authoritative and up-to-date information health information resources. This project has been funded in whole or in part with Federal funds from the National Library of Medicine, National Institutes of Health, Department of Health and Human Services, under Contract No. HHS-N-276-2011-00004-C with the University of Maryland Baltimore.
    • Importance of Chapter Membership: a 20-year Data Analysis

      Bandy, Sandra L.; Mears, Kim; University Libraries (Georgia Health Sciences University, 2012-10)
      Objective This project analyzes twenty years of recorded membership data from one of the fourteen chapters affiliated with the Medical Library Association (MLA). A search of the literature revealed national level program evaluations, new initiatives, and lessons learned but no Chapter-level articles specifically on membership. Outcomes will illustrate trends in membership and the possible need for stronger guidelines in retaining members. Methods Southern Chapter of the Medical Library Association has used FileMaker for recording membership information. Information includes years of service to the organization plus year joined, contact information, committee volunteer request, AHIP level, library type, and membership to MLA. The data collected is also used for the annual printed membership directory. Several data sets will be gathered to study the dynamics of the Chapter, longevity of members, and retention based on the introduction of a 2-year free student membership. Results From 1992 to 2012, the average membership for the Southern Chapter was 359 members. The highest membership occurred in 1996 with 402 members and the lowest membership occurred in 2006 with 285. Data trends demonstrate a drop in state membership levels in the corresponding state that hosted the annual meeting the following year. Membership rates also dropped when the annual meeting was hosted outside of the Chapter region. Development of new medical schools around the region resulted in a 62% increase in academic librarians’ membership while hospital librarians have seen a 45% drop in membership rates. Other data collected included types of MLA membership and librarians’ membership to the Academy of Health Information Professionals (AHIP). In 2008 the Chapter adopted a 2-year free student membership, with an average of 20 members per year since then. In its five year history, we have had 47 student members with 10 students joining the Chapter as a full member after the free membership expired. Conclusions According to the American Society of Association Executives (ASAE), the average retention rate is between 82%-90%. Southern Chapter’s overall retention rate is 89%, affirming the value librarians receive through membership. Data also revealed that student retention is 63%, which is below acceptable ASAE guidelines so additional support may be needed. A search of the literature suggested guidelines to increase retention rates of student members.
    • Transforming Print to Electronic Theses and Dissertations

      Bandy, Sandra L.; University Libraries (Augusta University, 2018-05-22)
      Objective: In response to a changing environment, the library collaborated with The Graduate School (TGS) to transition from print to electronic theses and dissertations (ETD). Since graduate students are writing their thesis and dissertations on a computer, the library initiated the electronic submission to provide long-term archiving of ETDs. This paper discusses new submission processes, including successful strategies and lessons learned. Methods: The University’s existing institutional repository is the new host for ETDs allowing students to upload their final thesis or dissertation into the repository. TGS worked with ProQuest to create an online ETD administrator for students. An ETD Microsoft Word template was designed and programmed by the library according to Graduate School specifications and approved by TGS administrators. TGS dissertation and thesis preparation manual was updated to reflect new formatting and template requirements and a second alternative template was developed for student use. To introduce the new process and workflow to PhD program directors, librarians attended TGS Council meeting. A Graduate School LibGuide for TGS was amended to provide instruction on the new ETD standards and process including the need for additional face-to-face instruction on ETDs. The Library developed an ETD bootcamp for the new process. Results: After reviewing the initial submission process, the library partnered with ProQuest to simplify their procedures. The library worked with ProQuest to create a Sword protocol for automatic deposits of metadata and PDF files to the repository. Students no longer deposit their final thesis or dissertation into the repository but only to ProQuest eliminating a step in the submission process. Conclusions: Collaborating with our university's Graduate School created a unique partnership that resulted in new library ETD services for graduate students. Future work with ETDs will focus on retrospectively digitizing the library’s print dissertations.
    • Trainee Therapist Personality, Technique Usage, and Helpfulness

      Sandlin, Samantha H.; Department of Psychological Sciences (Augusta University, 2020-12)
      The goal of the present study was to explore how trainee therapists’ differential technique usage and perceived helpfulness ratings of the techniques used in therapy relate to their personality characteristics. The NEO-FFI-3 was administered to 59 clinical and counseling graduate students prior to training to assess their self-reported personality traits. Then, during their first therapy course, trainees conducted four therapy sessions with a volunteer client. Trainees watched the videotape of their third session and rated the techniques they perceived themselves to have used and their view of how helpful those interventions were. Results showed a significant, negative relationship between trainee conscientiousness and their use of interventions aimed at helping clients identify contradictions in their thoughts, feelings, and behaviors. Moreover, significant associations were found between two personality traits and trainees’ perceived helpfulness ratings of their technique usage. Specifically, as trainees’ neuroticism increased, their perception of how helpful they were in helping their client gain a new perspective decreased. Conversely, as their extroversion increased, they perceived themselves to have been more helpful in assisting clients in gaining a new perspective. Notably, all statistically significant findings had a moderate effect size. Our findings provide preliminary conclusions about the relation between trainee personality characteristics and differential technique usage in sessions, as well as how helpful trainees perceived those techniques to be.

      Graham, Caroline; Hull College of Business (Augusta University, 2020-12)
      Prior research conducted by organizations such as the Organization for Economic Co-operation and Development (OECD) has shown that many people claim they feel secure with their knowledge of financial planning and management. However, as witnessed during the government shutdown, feelings are not the same as actions. If that was the case, then many people would have been able to cover their expenses despite missing a few paychecks. Moreover, whenever a financial literacy quiz has been provided to the public, history has shown that “less than ten percent of the respondents pass” (Martin, 2017) showing that financial literacy levels are low. Over the years, many people have gained more knowledge on saving strategies, budgeting, and the benefits of investing. In their report, the Federal Reserve found that, “when asked about their finances, 75 percent of adults say they are either doing okay or living comfortably. This result in 2018 is similar to 2017 and is 12 percentage points higher than 2013.” (The Federal Reserve, 2019, p. 1). However, the number of individuals still living paycheck to paycheck while drowning in debt is alarmingly high. A blogger from Equifax found that “56% of Americans don’t have any money left over at the end of the month after paying their bills” (Financial Literacy Survey: Do You Save for a Rainy Day?, 2019). This is caused by poor financial planning, living beyond one’s means or taking on too much debt, and sometimes, a combination of all three. This study will add to research by emphasizing the importance of financial literacy by evaluating the financial health of survey respondents and their knowledge of common concepts of finance. These concepts include interest, investments, and inflation. The respondents were recruited via Facebook and personal contact, such as family and classmates. The data collected will be used to examine how financial literacy varies across socioeconomic demographics. Lastly, the study will provide recommendations on ways financial education programs can improve to reach a larger audience and educate the public. These recommendations will be based on the survey responses on how people would like to receive financial education in the future.
    • Teaching Matters April 2021

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2021-04-01)
      Table of Contents: A Note from the Vice Provost, Innovation Updates (I Still Know What You Did Last Summer: SAVE THE DATE, Simulation Center Partners with AU Paramedic Program for Disaster Training, Chemistry Course Redesign Published in G2C Case Study Anthology, Greenblatt Library Honors First MCG Women Graduates, Cross-Disciplinary Teams at Augusta University Honored for COVID Response), Faculty and Staff Updates (Dr. Quentin Davis elected as a CUR Councilor in the Undergraduate Research Programs Division, IPSO Features Dr. Candace Griffith, Student Updates (Career Services April Events and Academic Success Center Update).
    • The effects of the topically applied non-ionic surfactants, pluronic F-68 and F-127 on wound healing in the ra

      Shahan, Michael H.; Department of Oral Biology (Augusta University, 1992-05)
    • Characterization of zebrafish mutant merlot as a non-mammalian vertebrate model for congenital anemia due to protein 4.1 deficiency

      Shafizadeh, Ebrahim; Medical College of Georiga (Augusta University, 2002-08)
      The zebrafish mutant merlot (mot) is characterized by onset of a severe anemia at 96 hours post fertilization. We performed whole mount RNA in situ hybridization and showed that ihe process of primitive erythropoiesis is not interrupted in the mot embryos. Blood analysis demonstrated that mot suffers from a severe congenital hemolytic anemia. Using the TUNEL assay, we detected apoptotic erythroid progenitors in the kidneys. We performed electron microscopic analysis and detected membrane abnormalities and a loss of the cortical membrane organization in the mot cells. We used positional cloning techniques with a candidate gene approach to demonstrate that mot encodes the erythroid specific isoform of protein 4.1R, a critical component of the red blood cell membrane skeleton. Sequence analysis of 4.1R eDNA detected nonsense point mutations in both alleles of mot resulting in premature stop codons. We performed linkage analysis and transgenic rescue experiments to provide further confirmation that the molecular defect in the protein 4.1R is the underlying cause of anemic phenotype in mot fish. This study presents the zebrafish mutant merlot as the first characterized non-mammalian vertebrate model of congenital anemia due to a defect in protein 4.1R integrity.
    • A study of the relationship between perceived social support, satisfaction with social support networks, and self-rated health in older adults

      Seagraves, Pat C.; School of Nursing (Augusta University, 1992-04)
      The purpose of this study was to examine the relationship between perceived social support, satisfaction with social support networks and self-rated health in older adults. The study used a cross-sectional correlational design to examine the hypothesis that perceived social support and satisfaction with social support networks would be positively correlated (p < .05} with scores on a selfrated health measure. The convenience sample consisted of forty-three subjects ranging in age from sixty-five to ninety-five years, with a mean age of 75.4 years. All subjects were able to speak and understand English, and were judged to have the physical ability to complete a written questionnaire packet. All subjects completed Pfeiffer's Short Portable Mental Status Questionnaire (SPMSQ} with no more than two adjusted errors, indicating intact mental functioning. The Personal Resource Questionnaire (PRQ-85} was used to measure perceived social support, and investigator developed measures were used to assess satisfaction with social support and self-rated health. A list of health problems common to older adults provided an index of actual health status. Pearson correlation coefficients were calculated for satisfaction with social support networks, age, self-rated health and the subscales of PRQ-85, Part II. While the hypothesis of the study was not supported, a significant inverse correlation was demonstrated between age and nurturance, indicating that as a person ages, the opportunity for nurturant behavior decreases. The results of the data analysis reflected the multiplicity and chronicity of health problems in this age group, but revealed that older people do not evaluate their own health according to the number or type of health problems they experience. Nor is their self-rated health score consistent · with the number and type of medications they take. Further, the data from this sample woula indicate that self-rated health in this age group is not dependent on one's perception of social support, nor their satisfaction with their so"cial support network.
    • AKAP350 : a centrosome associated scaffold protein

      Schmidt, Hank; Medical College of Georgia (Augusta University, 2000-06)
      A-kinase anchoring proteins (AKAPs) are recognized as key components of compartmentalization and transduction in intracellular cAMP signaling. They allow localization of the Type II cAMP-dependent protein kinase to specific subcellular domains, effectively positioning the enzyme near its substrate to await activation by cAMP. The role of AKAPs as protein scaffolds allows binding of multiple enzymes, regulatory molecules, and structural elements, functioning as a virtual platform for modulation of specific cellular events (i.e. membrane channel activity, receptor clustering). We have cloned a novel350 kDa AKAP (AKAP350) from human gastric eDNA, and identified partial clones in human lung and rabbit parietal cells. The genomic region containing AKAP350, found on chromosome 7q21, is multiply spliced, producing at least three distinct AKAP350 isoforms as well as yotiao, an NMDA receptorassociated protein. We identified three unique AKAP350 C-termini (AKAP350A, -B, and -C) resulting from alternative splicing of the 3' end of the gene. AKAP350 is associated with centrosomes, as well as with the cleavage furrow during anaphase and telophase by immunocytochemistry. Polyclonal antibodies to individual AKAP350 Cterminal splice variants demonstrate tissue dependent combinations of centrosomal and non-centrosomal distribution. In the polarized HCA-7 colon cell line AKAP350A is purely non-centrosomal while AKAP350B and -C are centrosomal. Anti-AKAP350C is limited to mitotic cells, suggesting that this isoform may be expressed only at entry into M phase. A yeast two-hybrid screen of a rabbit parietal cell library identified a novel TACC (Transforming Acidic Coiled coil Containing) protein family member as a ligand of the final pair of arginine residues iii the AKAP350A splice variant. A GFP fusion with the novel AKAP interacting protein verified co-localization with AKAP350 at the centrosome exclusively during mitosis. Microinjection of dividing sea urchin embryos with GST fused to the AKAP interacting protein arrested cell division. Therefore, the AKAP350 protein scaffold may function as a large docking station, providing kinase I phosphatase signals for coordination of cytoskeletal dynamics as well as cell division.
    • The relationship between level of hope and coping response in women with breast cancer

      Schlesselman, Susan M.; School of Nursing (Augusta University, 1991-05)
    • Endothelin-1 signaling and reactive oxygen species production in hypertension and type 1 diabetes mellitus

      Sasser, Jennifer Mayberry; Medical College of Georgia (Augusta University, 2005-07)
      Nitric oxide (NO) and endothelin-1 (ET-1) play important roles in the cardiovascular system, and alterations in these pathways.can have significant effects on the regulation of blood pressure and renal function. Reactive oxygen species (ROS) influence the production and actions of these two factors, and therefore modulate the biological effects ofNO and ET-1. Thus, the overall goal of these studies was to determine the impact of increased ROS and ET -1 production in the development of hypertension and diabetic kidney disease. We hypothesized that (1 )_ increased superoxide production and a dysregulation of endothelial NO synthase (NOS3) in small arteries result in reduced NO bioavailability in hypertension and (2) enhanced ET -1 production and endothelin A (ETA) receptor activation promotes renal injury in the settings of hypertension and diabetes. We found that basal NO/cGMP signaling is diminished in small mesenteric arteries ofDOCA-salt rats, and this decrease is associated with reduced NOS3 phosphorylation at two positive regulatory sites, but not superoxide production. Chronic angiotensin II (An g) infusion combined with a high salt diet increased the renal cortical and outer medullary ET -1 content. However, high salt diet; with or without Ang infusion, reduced inner medullary ET-1 content and increased urinary excretion ofET-1. These data indicate that chronic elevations in Ang levels and sodium intake produce differential effects on ET -1 levels within the kidney. Blockade of the ETA receptor with ABT -627 reduced renal injury in the streptozotocin model of type 1· diabetes. We found that oxidative stress was increased in hyperglycemic rats; however, the production of reactive oxygen species was not attenuated by ETA receptor blockade, indicating that the increased reactive oxygen species production observed in diabetes is not due to ETA receptor activation. Additionally, we found that urinary excretion of the metabolites of prostaglandin E2 (PGE2), prostacyclin, and thromboxane are all increased in hyperglycemic rats, and ETA receptor blockade reduced the excretion ofPGE2 metabolites. By obtaining a better understanding of reactive oxygen species production and ET -1 signaling pathways, we have gained a new perspective on the roles of these factors in the development of hypertension and diabetic renal disease.
    • In vitro mechanical analysis of full-arch mandibular implant-supported, complete fixed prostheis retainer screws after cyclic loading

      Sananez, Andreina J.; Medical College of Georgia (Augusta University, 2012-04)
      The use of implant-retained and supported prostheses has become a very successful treatment for completely edentulous patients. One of the most common fixed solutions involving implants consists of 5 to 7 implants supporting a framework upon which either porcelain or prefabricated acrylic resin denture teeth are added. A screw is utilized to attach the framework/prosthesis to the implants. Screw loosening is the second most common clinical complication in the implant-prosthesis system. If clinicians fail to detect worn or loose retaining screws, prosthetic fracture could occur, leading to more complicated, time consuming, and expensive repairs. Unfortunately, there is no established. parameter that indicates when to expect these complications, and there is no proven recall-maintenance protocol to prevent them. The aim of this study is to examine and compare differences among de-torque values and prosthetic retention screws, using a simulated 5 implant-supported, mandibular complete fixed prosthesis. Material and Methods: Nine groups, each with its respective control, using five Nobel Biocare implants and a milled titanium framework were fabricated, assembled and tested. Dynamic loading was p on the performed tested groups through a custom made loading device for anterior, posterior, and distal cantilevered segments of the prosthesis, calculated to simulate clinical usage time. Removal of screws after 2 years of simulated oral function was performed. Before and after testing, screws were evaluated with a Scanning Electronic Microscope (SEM), for presence of debris, thread striations and homogeneity. Control groups remained unloaded for the same time the loaded groups were tested. Results: Comparisons of the difference between initial tightening torque and de-torque screw values were performed between loaded/unloaded groups and with respect to implant position. The interaction between loaded and position was significant (p=0.002). The comparison between loaded/unloaded groups was not statistically significant (p=0.518). Loaded and unloaded groups were compared separately at each of the 5 implants position, which showed a significant difference (p=0.0002, a=0.001). The sequencing effect was only seen in the control groups and thus would only be relative to framework insertion. The sequence effect was found to be overcome by from loading and resulted in a totally different position related to screw tightness. Within the limitations of this in vitro study, it was concluded that sequence of torque application could play a role in the preload of screws even with a passive fit, regardless the load applied.
    • Role of endothelin-1(ET-1) in glomerular inflammation and glomerular permeability in normal and diabetic kidney

      Saleh, Mohamed Ahmed; Department of Pharmacology and Toxicology (Augusta University, 2010-11)
      Endothelin-1 (ET-1) is a potent vasoactive peptide implicated in the pathogenesis of hypertension and renal disease. The overall specific aim of this dissertation is to investigate the role of ET-1 in mediating glomerular inflammation and permeability, especially in diseases characterized by high activity of the ET-I system, such as diabetic nephropathy. The first study was designed to test the hypotheses that ET-I increases albumin permeability of glomeruli isolated from normal rats and that chronic ET-I infusion will increase glomerular permeability and inflammation independent of blood pressure. Glomerular permeability to albumin (P alb) was determined from the change in glomerular volume induced by exposing isolated glomeruli to oncotic gradients. Incubation of glomeruli taken from normal rats with ET-I at a concentration that did not produce direct glomerular contraction (I nM) significantly increased P alb, reaching a maximum after 4 hrs. Chronic ET-1 infusion for 2 weeks in Sprague-Dawley (SD) rats significantly increased P alb and nephrin excretion rate, effects that were attenuated in rats given an ETA receptor antagonist, ABT-627. Urinary protein and albumin excretion and mean arterial pressure (telemetry) were not changed by ET-1 infusion. Acute incubation of glomeruli isolated from ET -!-infused rats with the selective ETA antagonist significantly reduced P alb, an effect not observed with acute treatment with a selective ET e antagonist. Chronic ET -I infusion increased glomerular and plasma siCAM-1 and MCP-1 and elevated the number of macrophages and lymphocytes in renal cortices (CD68- and CD3-positive staining, respectively). These effects were all attenuated in rats given an ETA selective antagonist. These data support the hypothesis that ET -I directly increases glomerular permeability to albumin and renal inflammation via ETA receptor activation independent of changes in arterial pressure. The second study was designed to test the hypothesis that ETA receptor activation increases P alb and elevates pro-inflammatory markers in hyperglycemic rats. Male SD rats were given streptozotocin (STZ) or saline (sham). Half of the animals in each group received ABT- 627 beginning immediately after hyperglycemia had been confirmed. Glomeruli were isolated by sieving and P alb determined from the change in glomerular volume induced by exposing glomeruli to oncotic gradients of albumin. Glomerular nephrin expression was assessed by immunofluorescence, whereas urinary nephrin was measured by enzymelinked immunosorbent assay. Three and 6 weeks after STZ injection, proteinuria was significantly increased compared to sham controls and was significantly reduced by ABT-627 treatment. Palb was also increased at 3 and 6 wk post-STZ; ABT-627 had no effect on P alb or protein excretion in sham rats. Glomerular and plasma content of siCAM-1 and MCP-1 were significantly increased 6 wk after STZ. ABT-627 attenuated these increases. After 6 weeks of hyperglycemia, glomerular nephrin expression was decreased with a concurrent increase in urinary nephrin excretion; ABT -627 prevented glomerular nephrin loss in the hyperglycemic rats. These observations support the hypothesis that ET -I, via the ETA receptor, mediates the increase in proteinuria and P alb, possibly via nephrin loss, as well as early inflammation in the hyperglycemic rat. In the third study, we determined the actions of ETA and ETe receptors on measures of glomerular function and renal inflammation in the early stages of diabetic renal injury in rats. Six weeks after STZ-induced hyperglycemia, rats were given ABT-627 (5 mg/kg/d) a selective ETA antagonist; A-182086 (10 mglkg/d), a combined ETAIB antagonist; or vehicle for 1 week. Sham controls received STZ vehicle (saline). Hyperglycemia led to significant proteinuria, increased P alb, nephrinuria, and an increase in total matrix metalloprotease (MMPs) and transforming growth factor-beta 1 (TGF-~1) activities in glomeruli. Plasma and glomerular siCAM-1 and MCP-1 were elevated after 7 weeks of hyperglycemia. Daily administration of both ABT-627 and A-182086 for 1 week significantly attenuated proteinuria, the increase in P alb, nephrinuria, and total MMPs and TGF-~1 activity. However, glomerular siCAM-1 and MCP-1 expression was attenuated with ABT-627, but not A-182086 treatment. In summary, both selective ETA and combined ET AlB antagonists reduced proteinuria, glomerular permeability and restored glomerular filtration barrier components integrity, but only ETA selective blockade had anti-inflilmmatory and anti-fibrotic effects. We conclude that selective ETA antagonists are more likely to be preferred for treatment of diabetic kidney disease.
    • The Relationship among structure, technology, autonomy, decision making, nurse characteristics and the decision to call a resuscitation code on the patient who needs cardiopulmonary resuscitatio

      Russell, Katherine S.; Medical College of GA (Augusta University, 1997-08)
      In this study, the relationship among nursing unit structure, technology, autonomy, decision making, nurse characteristics and the timeliness of calling a resuscitation code was explored. The conceptual framework of the study was The Structural Interaction Model for Health Care Behavior (Colgrove, 1992), a model that combined and synthesized concepts from organizational theory, quality care, and patient-centered care. The hypothesized relationships were investigated using multivariate logistic regression and multiple regression analysis. A sample of 127 registered nurses and 127 patient resuscitation events from one hospital was used in the study. Nurses' perception of nursing unit structure, technology, autonomy and decision making were measured using four instruments. Nurse characteristics were obtained from the nurse demographic tool. Data required to stage the timeliness of calling a resuscitation code (early versus not early) was obtained from the patient's hospital record. Testing of the analytical model resulted in beginning support for elements that may contribute to the timeliness of calling a resuscitation code for the patient who may need cardiopulmonary resuscitation. These relationships pointed to the impact of structural factors and professional factors on the timeliness of calling a code. The findings were nurses with a baccalaureate degree or higher were more likely to call an early code as were nurses with less than a baccalaureate degree. Moreover, nurses that practiced on a unit with a more flexible nursing unit structure were more likely to call an early code than were nurses that practiced on a unit with a non- flexible unit structure. Nurses that were found to have a higher degree of normative decision making were more likely to call an early code than nurses that were found to have a lower degree of normative decision making. Further, there appeared to be a strong linear relationship between autonomy and the timeliness of calling a code. Nurses who perceived they were practicing with a higher degree of autonomy were more likely to call an early code than those who perceived they were practicing with a lower degree of autonomy.
    • Stress among parents of preterm and term infants hospitalized in the neonatal intensive care unit

      Russell, Guerry K.; School of Nursing (Augusta University, 1994-06)
      The Neonatal Intensive Care Unit (NICU) hospitalization of an infant serves as a significant stressor for parents. The purpose of this study was to determine whether stress levels differ between preterm and term parents as well as between mothers and fathers when the NICU hospitalization of an infant is experienced. Fifty-three parents completed the Parental Stress Scale: Neonatal Intensive Care Unit (PSS:NICU). Five two-way ANOVA's were computed in order to compare stress scores for preterm and term parents as well as mothers and fathers on each of the PSS:NICU's four subscales and for the instrument as a whole. No significant differences were found between preterm and term parents or mothers and fathers with regard to stress scores. These findings support the need for neonatal nurses to recognize all parents as being equally at risk for experiencing stress when the NICU hospitalization of an infant is experienced. The development of an individualized plan of care for each parent is imperative if adaptation to the NICU hospitalization is to occur.
    • Characteristics of fluoride flux and the absence of a vasopressin-like effect by fluoride in the isolated perfused rabbit cortical collecting duct

      Rouch, Alexander John; Department of Physiology and Endocrinology (Augusta University, 1989-06)
      Fluoride flux (JF) was measured in the isolated perfused rabbit cortical collecting duct (CCD) to determine some of the basic physiological characteristics of JF in this segment. Also, the effect of fluoride on hydraulic conductivity (Lp) in the CCD was assessed. Fluoride can increase cyclic AMP levels in a variety of tissues and the vasopressin-induced increase in Lp in the CCD is a cyclic AMPdependent event. To determine if fluoride would increase Lp. Lp was compared among 3 conditions: 1) control, (no fluoride or vasopressin); 2) with 1 or 5 mM .fluoride in the bath; and 3) with 25 J.LU/ml vasopressin in the bath. The Lp in condition 1 was not different from that in 2 (8.6 ± 1.8 vs 5.0 ± 2.7 cm/sec/atm X I0-7, respectively, n=5) (Data expressed as mean ± SE). Lp in condition 3 (112 ± 7.4 cm/sec/atm X 10-7) was significantly higher than that in 1 and 2 (p<.001). The effect of luminal-fluid pH on JF was assessed. In one set of experiments (n=7), JF determined with a pH of 6.1 was significantly higher than that with a pH of 7.4 (.027 ± .007 vs .008 ± .002 pmole/min/mm, respectively; p<.01). In another set (n=5), JF with a pH of 5.0 was significantly higher than that with a pH of 6.1 (.040 ± .004 vs .018 ± .003 pmole/min/mm, respectively; p<.01). Bath pH was always 7.4. Osmotically-induced, lumen-to-bath fluid flux (Jv) did not affect JF. A 40o/o reduction in the trans epithelial fluoride concentration gradient did not affect JF. The effects of acetazolamide and the disulfonic stilbene DIDS on JF were determined separately by measuring JF in the absence and presence of each agent. Neither of these agents significantly affected JF, although JF was reduced consistently with acetazolamide. JF measured with bicarbonate-buffered solutions (.025 ± .003 pmole/min/ID.Iil, n=30) was significantly higher than that with HEPES-buffered solutions (.012 ± .003 pmole/min/mm, n=16) (p<.02). Transepithelial voltages which ranged from +10 to - 104 mV did not affect JF. It was concluded that: 1) fluoride did not affect Lp: 2) Jv did not affect JF: 3) pH gradients affected JF: 4) acetazolamide and DIDS did not affect JF: 5) JF was affected by the buffer of the solution: and 6) the CCD permeability for fluoride is relatively low.
    • Expression of the virion associated host shutoff protein in equine herpesvirus type-1 RacL strain

      Rossman, Joanne F.; Medical College of Georgia (Augusta University, 1998-07)
    • Studies on multiple aspects of estrogen action

      Rosser, Mary Lee; Department of Physiology and Endocrinology (Augusta University, 1991-05)
    • Neuronal and astroglial injury and recovery from stroke-induced depolarizations

      Risher, William Christopher; Medical College of Georgia (Augusta University, 2010-12)