Now showing items 1-20 of 5574

    • EFFECTS OF SODIUM BICARBONATE ON GLUCOSE HOMEOSTASIS AND BLOOD PRESSURE IN CHRONIC KIDNEY DISEASE

      Mannon, Elinor; Department of Philosophy (Augusta University, 2021-10)
      Sodium bicarbonate (NaHCO3) is a therapeutic used in chronic kidney disease (CKD). NaHCO3 is typically used to treat metabolic acidosis, but clinical studies have indicated that NaHCO3 supplementation may slow CKD progression. As such, NaHCO3 is now given to patients with CKD to slow the decline of glomerular filtration rate. However, the consequences of chronic NaHCO3 supplementation in CKD remain unclear. Acidosis has been associated with insulin resistance, and correction of acidosis with NaHCO3 was reported to improve insulin sensitivity. Our goal in Aim 1 was to determine whether acid and alkali loading would promote loss of acid-base homeostasis and consequently decrease insulin sensitivity. We determined that the blood glucose response to insulin is enhanced following renal mass reduction, and that this response is not reversed by an acidosis. Additionally, the development of an alkalosis did not impair the blood glucose response to insulin. Alkali can promote potassium (K+) wasting, and an association between K+ wasting and insulin resistance has been identified in clinical and basic science research. Our goal in Aim 2 was to identify whether chronic NaHCO3 treatment may promote loss of insulin sensitivity through effects on K+ status. We determined that chronic NaHCO3 treatment impairs insulin sensitivity when combined with other K+ wasting stimuli. K+ deprivation alone also impaired the blood glucose response to insulin, however these impairments in insulin sensitivity were not directly related to decreases in intracellular [K+]. Salt-sensitivity increases as functional renal mass declines, and chronic sodium (Na+) loading with NaHCO3 may contribute to hypertension in patients with CKD. Our goal in Aim 3 was to investigate whether NaHCO3 loading promotes similar levels of Na+ and volume retention, and hypertension as sodium chloride (NaCl) loading does in a rat model of CKD. We found that NaHCO3 was pro-hypertensive, but to a lesser degree than NaCl, despite similar amounts of Na+ and volume retention. From these studies we concluded that NaHCO3 does not improve insulin sensitivity through its effects on acid-base status. Further, access to dietary K+ may improve insulin sensitivity with chronic NaHCO3 treatment. Finally, NaHCO3 can promote hypertension in CKD.
    • Evidence to Support Environmental and Contextual Modifications to Improve Participation in Community Events for Children with Disabilities

      Howell, Alexis; Priest, Teri; Sandy, Emily; Williams, Meghan; Kearney, Pamalyn; Rosche, Mallory; Department of Occupational Therapy (Augusta University, 2021-09)
      • Current literature has shown that children with disabilities participate less often and are not as engaged when participating compared to children without disabilities • This lack of participation might occur due to the interaction between environmental, attitudinal, and social barriers at home, at work, and during play • Participation allows children to learn about societal expectations, appropriate communication with others, develop friendships and skills they need to become successful at home, in communities, and in life • Participation is regarded as an essential aspect of child health and well being • This study aims to determine what evidence is available to support modifications to environments and contexts to improve participation in community events for children with disabilities under the age of 18.
    • Evidence Related to Setting, Structure, and Outcomes of Occupational Therapy Nontraditional Level II Fieldwork: A Scoping Review

      Graham, Maggie; Hartman, Kylee; LeMasters, MacKenzie; Moore, Brette; Reed, Lilly; Thrysoe, Gitte; Vera, Laurie; Kearney, Pamalyn; Department of Occupational Therapy (Augusta University, 2021-09)
      Definition: Nontraditional Fieldwork (NTFW): Site where OT services may be unavailable prior to implementation • May be supervised by an employee of organization1 or an OT • ACOTE: full time FW hours for 24 weeks graduation eligibility2 Gaps in the literature include: • Definition of NTFW • Amount of supervision • Sample size variations between traditional FW and NTFW • How students engage with patients in NTFW settings • Information to support and inform all stakeholders about difficulties in NTFW settings • Results on student educational success in NTFW Purpose: to address the gap in the literature by looking at widely available sources to provide relevant insight into nontraditional Level II Fieldwork for the interested audience.
    • Assessments Evaluating the Relationship Between Psychosocial Factors and Upper Extremity Trauma: A Scoping Review

      Coleman, Isabelle; Glaze, Morgan; Griffin, Caroline; Holbrooks, Sarah Beth; Moore, Kristen; Department of Occupational Therapy (Augusta University, 2021-09)
      Objectives of Presentation: At the conclusion of this presentation, attendees will: ● Identify 3 current assessments available that evaluate the psychosocial components of upper extremity (UE) recovery after trauma. ● Discuss 3 of the most common types of psychosocial challenges often experienced by individuals with UE trauma. Clinical/Research Question: What assessments are available for examining the relationships between psychosocial factors and UE trauma during rehabilitation of adults with UE trauma?
    • A Scoping Review of International Interprofessional Education and Collaborative Evidence

      Smith, Gloria; Holton, Emily; Peeler, Michaela; Stancil, Reagan; Johnson, Stephanie; Department of Occupational Therapy (Augusta University, 2021-09)
      • Gap in literature: Best practices for allied health international interprofessional collaboration and education • Collaboration better coordinates interprofessional care for best patient centered focus. • Interprofessional education improves health outcomes, sets foundation for future health care professionals, and provides basis for communication, collaboration, and patient care. • Allied Health Professions: Those which require practitioners to attend a higher level institution, obtain a certificate, and work collaboratively with other healthcare professionals to provide care to individuals suffering from acute and chronic diseases, rehabilitation services, and dietary and nutrition services in several settings. Research Question: Among allied health science disciplines, what is the evidence supporting outcomes as related to international interprofessional education and collaborative experiences?
    • Intraprofessional Educational Activities Implemented by Occupational Therapy Programs in the United States

      Eller, Sydney; Morris, Emma; Parker, Olivia; Ruble, Charlotte; Speciale, Natalie; Usry, Jenna; Watford, Patricia; Department of Occupational Therapy (Augusta University, 2021-09)
      ● Intraprofessional collaboration has been shown to increase:2. 3 ○Confidence ○Patient care ○Ethical compliance ○Cost-effective care ●The accrediting body for occupational therapy education, ACOTE, requires that OT and OTA programs address: ○Intraprofessionalcollaboration ○How to engage in the consultative process, evaluation process, and treatment process with their intraprofessionalcolleagues.1 ●An unpublished survey from 2019 found that 68% of programs included intraprofessional collaboration in their curriculum4despite requirements from ACOTE.1 ●Our research questions are: What is the prevalence of intraprofessional collaboration in occupational therapy education programs and what strategies are used to implement intraprofessional activities?
    • Perceptions of International Fieldwork Experiences on Professional and Personal Development for Occupational Therapy Students

      Bauknight, Rebekah; Cutcliff, Kelley; Ford, Emma; Lenz, Kendall; Long, Cassidy; Swift, Sharon; Department of Occupational Therapy (Augusta University, 2021-09)
      The Augusta University Occupational Therapy Program offers two Level I international fieldwork experiences (IFEs) to Jamaica each year. One IFE is offered early in the curriculum, while the other is offered later. •Existing research demonstrates that International Educational Experiences (IEEs) allow students to develop: •Valuable personal and professional skills.1 •Improved communication, patient care, and adaptability.2 •Autonomy and lifelong learning.3 •Previous work from students at Augusta University evaluated differences between domestic and international occupational therapy students’ perceptions on Level I international fieldwork.4,5 •Images 1-3 demonstrate student engagement with clients during the IFE, and demonstrate previous findings that overall, the IFE was found to more greatly impact student’s perceived personal and professional development than domestic FW. •Further research is needed to determine if the amount of credit hours obtained prior to the IFE has an impact on students’ perceived development. The purpose of this studywas to compare Early Program Participants’ (EPPs) perceptions versus Later Program Participants’ (LPPs) perceptions of the Level I IFE on their personal and professional development. •EPPs: 14 credit hours obtained prior to the trip. •LPPs: 32+ credit hours obtained prior to the trip. Hypothesis: LPPs’ average scores pertaining to perceived personal and professional development would be greater than EPPs’ due to advancement in the curriculum, allowing for increased opportunities to gain confidence and apply OT knowledge.
    • Prevalence of Holistic Admission Criteria Among Entry-Level Occupational Therapy Programs

      Taylor, Kristian; Nguyen, Cat-Tien; Grant, Jenny; Brewster, Mary Beth; Barrett, Mary Alice; Benevides, Teal; Cosper, Sharon M.; Department of Occupational Therapy (Augusta University, 2021-09)
      Objectives of Presentation: At the conclusion of this poster, attendees will: 1. Describe the difference between holistic admissions and academic metric- only procedures implemented by entry-level occupational therapy programs. 2. Discuss the relationship between implementation of holistic admissions criteria and entry-level occupational therapy program ranking. Research Purpose: The purpose of this study is to compare the holistic admissions criteria used by the top fifty ranked entry-level occupational therapy master’s and doctoral programs to the fifty lowest ranked programs.
    • Disparities in Autism Educational Classification in the United States: A Summary of Public-School Data in Three States in Autism Educational Classification in the United States: A Summary of Public-School Data in Three States

      Bevil, Bailey; Breitmann, Shelby; Dyals, Bethany; Franke, Catherine; Hassett, Anna; Padgett, Gracie; Benevides, Teal; Department of Occupational Therapy (Augusta University, 2021-09)
      • Problem: Limited research exists to describe and understand disparities in autism spectrum disorder (ASD) classification across counties in the United States. A classification of ASD is valuable as it provides the child with greater access and provision of resources both within and outside of the school system. • Research has shown that definitions and evaluation procedures vary among states (Pennington et al, 2014). • Some individuals who have autism spectrum disorder do not obtain a diagnosis of ASD until they are into their adolescence or adulthood (Centers of Disease Control and Prevention [CDC], 2020). • Early intervention for autism spectrum disorder can increase positive outcomes (CDC, 2020). • Only 58% of children who meet the criteria for a diagnosis of autism spectrum disorder have it documented in their education or health records (Mandell et al, 2009). • Purpose Statement: This study sought to collect data demonstrating ASD disparities in three states, Massachusetts, Louisiana, and New York, in the United States as it relates to classification and accessibility to school-based services.
    • Bioactivity and mechanism of action of resveratrol, a polyhenolic phytoalexin, in sickle cell disease

      Agyekum, Davies G.; Medical College of Georgia (Augusta University, 2013-07)
    • Physicians' perceived incentives for association with nurse practitioners in the delivery of primary care

      Adinaro, Denise; School of Nursing (Augusta University, 1980-08)
      The purpose of this study was to identify those factors which physicians , currently associated with nurse practitioners, perceive as incentives in their motivation to associate with these nurse practitioners in providing primary care. A mail survey was sent to nurse practitioners and their associate physicians throughout the State of Georgia, with two follow-up postcard mailings. Data were collected for a 4 week period and a 30.46 return was obtained. A mean ranking of the identified incentives was performed. Two major categories of incentives were identified . To increase the quality of care was considered to be most important and to expand the services offered in general was rated second as incentives for physician association with nurse practitioners.
    • A NOVEL NETWORK BASED LINEAR MODEL FOR ENRICHMENT OF SYNERGISTIC DRUG COMBINATIONS

      Li, Jiaqi; Department of Physiology (Augusta University, 2021-07)
      Drug combination therapies can improve drug efficacy, reduce drug dosage, and overcome drug resistance with respect to cancer treatments. Current research strategies to determine which drug combinations have a synergistic effect rely mainly on clinical or empirical experience and screening predefined pools of drugs. Given the number of possible drug combinations, the speed and scope to find new drug combinations are very limited using these methods. Due to the exponential growth in these combinatorials, it is difficult to test all possible outcomes in the lab. Several large-scale public genomic and phenotypic resources that provide data from single drug-treated cells as well as data from small molecules deliver a wealth of cellular response information. This data gives opportunity to overcome limitations of the current methods. The development of a new strategy for advanced data processing and analysis that includes a computational prediction algorithm is highly desirable. Because of this, a program was written that predicts synergistic drug combinations using gene regulatory network knowledge and an operational module unit (OMU) system generated from single drug genomic and phenotypic data. As a proof of principle, we applied the pipeline to a group of anticancer drugs and demonstrated how the algorithm could help researchers efficiently find possible synergistic drug combinations using single drug data to evaluate all possible drug pairs.
    • Supplemental Data and Material for Assessing the Health Information Seeking Behaviors and Needs of Nurses in Skilled Nursing Facilities

      Kouame, Gail; Yang, Frances; Hendren, Steph; University Libraries; Georgia War Veterans Nursing Home (2021-07-14)
    • Studies on calcium transport of the sarcoplasmic reticulum in skinned cardiac muscle

      Zhu, Yu; Department of Physiology and Endocrinology (Augusta University, 1990-11)
    • Angiogenesis-associated gene expression changes in surgical skin flaps of diabetic rats

      Zhou, Miao Xian (Cindy); Medical College of Georgia (Augusta University, 2010-07)
    • Aquaporin 3 in keratinocyte differentiation

      Zhan, Xiangjian; Medical College of Georgia (Augusta University, 2003-08)
      Aquaporin 3 (AQP3) is a channel that transports both water and glycerol. AQP3- null mutant mice exhibit skin defects, including impairment of water holding capacity, barrier recovery and wound healing and decreased glycerol content. We hypothesized that AQP3 is involved in the regulation ofkeratinocyte proliferation and differentiation and this regulation is mediated, at least in part, by the functional interaction between AQP3 and phospholipase D (PLD). Here we demonstrate that AQP3 expression was down-regulated at the transcriptional level and glycerol uptake was reduced when primary mouse keratinocytes were induced to differentiate. In co-transfection experiments, we found that AQP3 decreased the promoter activity of keratin 5, a keratinocyte proliferation marker, but increased the promoter activity of keratin 10 and involucrin, an early and intermediate keratinocyte differentiation marker respectively. These results suggest that AQP3 is a regulator of early keratinocyte differentiation. In further investigatjons to determine the sigualing function of AQP3 in regulating keratinocyte differentiation, we found using sucrose gradient centrifugation, irnmunoprecipitation analysis, confocal microscopy that AQP3 and PLD2 were colocalized in lipid rafts. In addition, we demonstrated that AQP3 could contribute to the synthesis of phosphatidylglycerol (PG) and that PLD2 was able to utilize glycerol as a substrate to synthesize PG. These data suggest that AQP3 transports glycerol for use as a physiological primary alcohol substrate for-adjacent PLD2 to generate PG. Our results, together with the reports that PG is an activator of protein kinases (PKqm and PKCe) and also contributes to protein-protein interactions in membranes, suggest that glycerol AQP3-PLD2-PG is a potential signaling pathway in regulating keratinocyte differentiation.
    • EFFECTS OF ATTENUATION OF a8 AND a6 INTEGRINS ON THE DEVELOPMENT OF CIDCKEN OPTIC TECTUM

      Zhang, Zhiqiang; Medical College of Georgia (Augusta University, 1997-05)
    • Characterization of leydig cell development in the rat testis

      Zhai, Juan; Medical College of Georgia (Augusta University, 1996-05)
    • CURS Connection Summer 2021

      Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2021-06)
      Table of Contents: First AU Undergraduates Earn a Distinction in Research; Summer Scholars Symposium; Time to Prep Fall Grant Proposals; Seeking CURS Ambassadors;
    • Teaching Matters July 2021

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2021-07-01)
      Table of Contents: A Note from the Vice Provost; Innovation Updates (Summer Instructional Development Series was a Success; Faculty Highlights (IPSO Features: Dr. Mostafa Khater, CURS 2021 Mentor of Excellence Award); Student Opportunities (On Campus Student Employment Fair, Pizza and a Plan with the Provost)