Now showing items 1-20 of 5030

    • Teaching Matters July 2020

      Kelehear, Zach; Office of the Vice Provost for Instruction (Augusta University, 2020-07-01)
      Table of Contents: Transparency in Learning and Teaching (TILT), IPSO clients research why elderly people are more susceptible to COVID-19, ISC Prepares for a Return to Face-to-Face Instruction, Greenblatt Library receives funding to develop data literacy training modules, Student Updates (Record Number of Honors Students Published, Scholars Present Research in a Virtual Symposium, Study Abroad 2021 Programs, AAMI Mentoring, JAG Pals Providing Real Support in Virtual Times, Does Your Department Need a Student Worker?)
    • CURS Connection May/June 2020

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-06)
      Table of Contents: Happy Birthday SSP!: CURS Summer Scholars Program Turns 10CURS: A Year in Pictures, Reflections by Undergraduate Researchers, Get Involved (Arsenal Undergraduate Research Journal, Seeking CURS Ambassadors, Undergrad Research Advising, and Faculty: Take your UR Mentorship in New Directions)
    • CURS Connection April 2020

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-04)
      Table of Contents: Congratulations to Dr. Sabbatini, Biological Sciences: 2020 CURS Mentor Excellence Award, Congratulations Summer Scholars Program Awardees!, Research Week Recap, Get Involved (Arsenal Undergraduate Research Journal and Undergrad Research Advising)
    • CURS Connection March 2020

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-03)
      Table of Contents: We're Still Here!, Congratulations Spring Grant Awardees!, Ayala Presents to Georgia Legislators, Take Note (Phi Kappa Phi (would have been) Presenters, Call for Nominations: Mentor Excellence Award), Get Involved (Summer Research Opportunities through NSF and Undergrad Research Advising)
    • CURS Connection February 2020

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-02)
      Table of Contents: Student Researcher Spotlight: Vinaya Alapatt, B.S., Meet the CURS Ambassadors, Upcoming Events, Student Resources (Upcoming Workshop: Oral and Poster Presentation Workshop, Undergrads: Publish Your Work!, Phi Kappa Phi Student Research and Fine Arts Conference, Summer Research Opportunities through NSF, Follow Us on Social Media, CURS Advising)
    • CURS Connection January 2020

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-01)
      Table of Contents: Congratulations Dr. Brandon Cromer and Dr. Laurence Miller!, Student Research Series: Rachel Hammesfahr, Senior, Biology major and Ananya Chakraborty, Senior, Cell and Molecular Biology Major, Upcoming Events, Faculty Resources (Call for Proposals and Research and Travel Grants), Student Resources (Apply to be a CURS 2020 Summer Scholar and Phi Kappa Phi Student Research and Fine Arts Conference), Summer Research Opportunities through NSF, Advising, Announcements (Follow on social media, chemical and lab safety training, The Arsenal is seeking submissions)
    • Bone regenerative response following bone augmentation using hydroxyapatite with and without growth factors

      Sohn, Jeong-Yeol; School of Graduate Studies (1997-09)
      The purpose of this study was to determine whether adding transforming growth factor-13 (TGF-13) which is known to promote osteogenesis or 15 amino acid polypeptide obtained from collagen type I (P-15) which is known to enhance DNA synthesis in cultured fibroblasts, would enhance the osseoint~gr.ation- of porous anorganic bovine bone block (HA-block) to mandibular bone surface. Total of 45 rabbits were divided into three equal groups. The buccal side of the mandible in ea.ch anesthetized animal was surgically exposed,. decorticated and 10 x 5 x 4 mm. HA (Group I), HA+ TGF-13 (Group II) or HA + P-15 (Group III) blocks. were affixed to .host bone using two, titanium screws. Animals were sacrificed, 1 wk, 4 wks and 8 wks after surgery. A core of the implant· and underlying host bone was used to determin.e osteocalcin using Western and Slot blot analyses before perfusing the animals with 4% forma}in. The contralateral sides were only decorticated and served as sham controls. The interface between the HAblock and the ho.st bone showed a signifi.cantly higher (P<0~05) number of mesenchymal cells in the HA + TGF--P. and HA + P-15 one week group when c.ompared. to HA-alone. This numb.er of mesenchymal ·cells declined significantly .by the 4th and 8th weeks. The proliferating cell nuclear antigen (PCNA) index using immunohistochemistry als.o showed a significant increase in the one week groups and· then also declined. Alkaline phosphatase, osteocalcin, bone volume, and new bone formation were all significantly increased by the 4th and 8th weeks and were significantly higher in the HA + TGF-13 and HA + P-15 at 4 wks after surgery. In addition, the macropores of the lower halves of all blocks were filled with new bo.ne. The den~ity of the newly formed bone was comparable to the control bone. These res.ults indicate that anorganic :bovine bQne blocks are osteoconductive and their pores permit growth of new bone. The adding of TGF-P or P-15 enhanced all parameters of osteogenesis at the mandibular bone surface.
    • CURS Connection November/December 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-12)
      Table of Contents: Undergraduate Research Fair a Success, Student Research Series: Kyle Cartledge and Farron Aaronson, Mathematics and Isabella Santana, Cell and Molecular Biology, Georgia Undergraduate Research Conference (GURC), Faculty Resources (Faculty Information Sessions and Call for Summer Scholar Proposals), Student Resources (Vascular Biology Center Tour and High Five My Faculty: CURS Offering New Mentoring Award), Mark Your Calendars!, The 21st Annual Phi Kappa Phi Student Research & Fine Arts Conference.
    • CURS Connection October 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-10)
      Table of Contents: First Annual Undergraduate Research Fair, #Research News (Calling All Student Researchers and Chemical Safety Partners with CURS: Chemical and Lab Safety Training Comes to Summerville), Student Research Series: Nitish Sood and Anish Sangari, Cell and Molecular Biology, Leslie Duncan, Cell and Molecular Biology, Upcoming Events, Next Steps in Research Workshop, #ResearchNews (Calling Faculty Mentors, Art and Design Meet and Greet, and High Five My Faculty: CURS Offers a New Mentoring Award)
    • CURS Connection September 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-09)
      Table of Contents: Communications Student Involved in Multiple Scholarly Projects, High Five My Faculty: CURS Offers a New Mentoring Award, Student Research Series (Justin Brown, English major, Reeya Patel and Chandani Patel, Cell/Molecular Biology), Upcoming Events, #ResearchNews (Last Chance for 2019 GA Undergraduate Research Conference and Calling Faculty Mentors), #InTheKnow (Still Accepting Ambassadors! and Save the Date).
    • CURS Connection August 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-08)
      Table of Contents: Summer Scholars Symposium, Changes Coming in CURS Grant Opportunities, Student Research Series (Sabrina Nacci, English major, kicked off the Student Research Series (formerly known as Brown Bag), Upcoming Events, #ResearchNews (Call for Abstracts and CURS Ice Cream Social), Call for Nominations: CURS Ambassadors
    • CURS Connection June/July 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-07)
      Table of Contents: Summer Scholars Program Off to a Great Start, Fall Deadlines for Mini Grants, CURS in the Community, CURS Welcomes First Official Student Ambassador, Get Involved! (Undergraduate Research Portal (UROP) Helps Match Mentors and Students and HOW I INVESTIGATE: What does YOUR research time look like? Share it!).
    • CURS Connection May 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-05)
      Table of Contents: Ziembrowski Receives 2019 Mentor Excellence Award, University Scholars Program Students Present to SRNL Scientists, Summer Scholars Program Gets Underway, Undergrads Get a Closer Look at Cancer Research,
    • CURS Connection April 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-04)
      Table of Contents: AU Students Present Research to GA Legislators, Student Research Seminar: Deanna Doughty (Cellular & Molecular Biology major) and Michaela Mack (Mathematics major), Upcoming Events, #ResearchNews (Researcher Speaks with Undergraduates and Kinesiology Research Day), Congratulations!: CURS is pleased to announce our 2019 Summer Scholar students and faculty mentors!, Call for Nominations: CURS Ambassadors.
    • CURS Connection March 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-03)
      Table of Contents: Research Week is MARCH 11-15!, Mentor Highlights (Featured Mentor: Dr. Eric Numfor, Congratulations! Spring Grant Awards, Call for Nominations Mentor Excellence Award & CURS Ambassadors, Seeking CURS Ambassadors!), #ResearchNews (Chemical and Lab Safety Training (Health Sciences Campus), #JAGSWAG Stop by and grab a button!, 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference)
    • CURS Connection February 2019

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-02)
      Table of Contents: Message from the Director, Happenings at CURS (Arsenal: The Undergraduate Research Journal of Augusta University, Student Spotlight: Simran Mehrotra), What We Do: Undergraduate Research Opportunities Portal (UROP), Save the Date, This Month's Upcoming Events.
    • CURS Connection November 2018

      Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2018-11-26)
      Table of Contents: Don't miss the CURS Meet and Greet, Welcome Dr. Davis!! Check out our new Director of CURS, Chemical and Lab Safety Training, Opportunities to Present (33rd Annual NCUR, 8th Annual Lighting the Dream of Medicine Conference, Student Research Seminars)
    • Characterization of a Cyclic Peptide (ADO5) as a Novel Inhibitor of the Hsp90 Chaperoning Machine

      Fang, Wayne; Department of Biological Sciences (Augusta University, 2020-05)
      Protection of oncogenic proteins is the foundation of many hallmarks of cancer. Based on this, hsp90 inhibitors have emerged as a potentially potent strategy for cancer treatment. The clinical efficacy of the earlier Hsp90 inhibitors remains unsatisfactory, in part due to their induction of heat shock response and anti-apoptotic mechanisms in cancer cells. To identify alternative therapeutic agents without these effects, we have developed a cell-free high-throughput screen (HTS) platform based on the folding of progesterone receptor (PR) by the core components of the Hsp90 chaperoning machine. During our initial screening of 175 natural products from North African medicinal plants, we discovered the cyclic peptide AD05 as a novel Hsp90 inhibitor. AD05 has shown a powerful antitumor activity against various cancer cell lines including HeLa, Hs578T, MDA-MB231, MDA-MB453, E0771, THP1, and U937. Western blot analysis revealed that AD05 destabilizes Hsp90 client proteins without inducing heat shock response as indicated by lack of upregulation of Hsp70, Hsp40 and Hsp27. Remarkably, AD05 does not induce apoptosis but rather triggers autophagy in various cell lines.
    • The Effect of PFOA on ERα+ and ERα- Human Breast Cancer Cell Lines

      Gaw, Victoria; Department of Biological Sciences (Augusta University, 2020-05)
      Perfluorooctanoic acid (PFOA) is a man-made chemical that belongs to a large group of fluorotelomers. PFOA is used to manufacture both industrial and consumer products and individuals can be exposed to PFOA through ingesting PFOA-contaminated water or food. While the long-term effects of perfluorooctanoic acid are largely unknown, there is increased evidence suggesting it to be an endocrine disruptor. Studies have shown that PFOA binds to and activates the peroxisomeproliferator-activated receptor α (PPARα), which can regulate the expression of other genes and receptors such as the other PPAR isoforms as well as estrogen receptor α (ERα). Previous experiments in our lab demonstrated that PFOA treatment of MCF-7 breast cancer cells (an ERα positive cell line) decreased ERα mRNA and protein levels, and decreased cell viability by ~20% within 48h of treatment. However, these cells were treated in the absence of fetal bovine serum (FBS), a cell culture additive that contains important growth factors. When we repeated these experiments without serum withdrawal, we initially noted a tendency towards increased proliferation in MCF-7 cells treated with 50µM and 100µM PFOA at both 24h and 48h compared to control. To further examine the role of ERα in PFOA-induced proliferation, we carried out additional experiments in another ERα positive cell line, T47-D, as well as an ERα negative cell line, MDA-MB-231. All three cell lines showed a tendency for increased viability. These data suggest that the PFOA-induced increase in cell viability in these cell lines is not dependent on ERα expression. In addition, the opposing effects of PFOA on proliferation in MCF-7 cells in the presence and absence of FBS demonstrates the importance of accurately and completely reporting cell culture and treatment conditions.