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    Heat shock response in CHO mammalian cells is controlled by a nonlinear stochastic process.

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    Authors
    Lipan, Ovidiu
    Navenot, Jean-Marc
    Wang, Zixuan
    Huang, Lei
    Peiper, Stephen C
    Issue Date
    2007-10-30
    URI
    http://hdl.handle.net/10675.2/96
    
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    Abstract
    In many biological systems, the interactions that describe the coupling between different units in a genetic network are nonlinear and stochastic. We study the interplay between stochasticity and nonlinearity using the responses of Chinese hamster ovary (CHO) mammalian cells to different temperature shocks. The experimental data show that the mean value response of a cell population can be described by a mathematical expression (empirical law) which is valid for a large range of heat shock conditions. A nonlinear stochastic theoretical model was developed that explains the empirical law for the mean response. Moreover, the theoretical model predicts a specific biological probability distribution of responses for a cell population. The prediction was experimentally confirmed by measurements at the single-cell level. The computational approach can be used to study other nonlinear stochastic biological phenomena.
    Citation
    PLoS Comput Biol. 2007 Oct 5; 3(10):e187
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pcbi.0030187
    Scopus Count
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    Department of Pathology: Faculty Research and Presentations

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