Show simple item record

dc.contributor.authorGutsaeva, Diana R.
dc.contributor.authorParkerson, James B.
dc.contributor.authorSchaub, Robert G.
dc.contributor.authorKurz, Jeffrey C.
dc.contributor.authorHead, C. Alvin
dc.date.accessioned2013-02-07T20:56:46Z
dc.date.available2013-02-07T20:56:46Z
dc.date.issued2009-12
dc.identifier.urihttp://hdl.handle.net/10675.2/931
dc.descriptionPosteren_US
dc.description.abstractAdhesive interactions between circulating red blood cells (RBC), leukocytes, and endothelial cells in post capillary venules have been implicated as a contributing factor to the pathogenesis of vaso-occlusion, the major cause of morbidity and mortality associated with sickle cell disease (SCD). Endothelial cell P-selectin, a member of the selectin family of cell adhesion molecules, plays a key role in leukocyte recruitment as well as in the adhesion of sickle RBC (sRBC) to the endothelium. The expression of P-selectin is elevated in SCD and the interaction of P-selectin and its ligands is likely to contribute to impairment of the microvascular flow and thereby to the development of painful vaso-occlusive episodes. Aptamers, short single-stranded oligonucleotides that fold into complex 3-D structures and bind to ligands, have been developed for a wide range of therapeutic targets. Although anti-P-selectin aptamers have been shown to inhibit leukocyte rolling in vitro and to display efficacy in mouse models for inflammation, anti-adhesion activity of anti-P-selectin aptamers has never been evaluated in SCD.
dc.description.sponsorshipArchemix Corp.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Hematologyen_US
dc.relation.ispartofseriesASH;2009_H01
dc.subjectSickle cell diseaseen_US
dc.subjectAptameren_US
dc.subjectP-selectinen_US
dc.subjectVaso-occlusionen_US
dc.titleSingle-Stranded Oligonucleotide Aptamer Binding to P-Selectin Inhibits Adhesion of Sickle Red Blood Cells and Leukocytes to Endothelial Cells in Sickle Cell Disease Model Mice: Novel Therapeutics for Vaso-occlusive Episodesen_US
dc.contributor.corporatenameMedical College of Georgiaen_US
dc.contributor.corporatenameDepartment of Anesthesiology and Perioperative Medicineen_US
refterms.dateFOA2019-04-10T01:39:58Z
html.description.abstractAdhesive interactions between circulating red blood cells (RBC), leukocytes, and endothelial cells in post capillary venules have been implicated as a contributing factor to the pathogenesis of vaso-occlusion, the major cause of morbidity and mortality associated with sickle cell disease (SCD). Endothelial cell P-selectin, a member of the selectin family of cell adhesion molecules, plays a key role in leukocyte recruitment as well as in the adhesion of sickle RBC (sRBC) to the endothelium. The expression of P-selectin is elevated in SCD and the interaction of P-selectin and its ligands is likely to contribute to impairment of the microvascular flow and thereby to the development of painful vaso-occlusive episodes. Aptamers, short single-stranded oligonucleotides that fold into complex 3-D structures and bind to ligands, have been developed for a wide range of therapeutic targets. Although anti-P-selectin aptamers have been shown to inhibit leukocyte rolling in vitro and to display efficacy in mouse models for inflammation, anti-adhesion activity of anti-P-selectin aptamers has never been evaluated in SCD.


Files in this item

Thumbnail
Name:
Gutsaeva_ASH2009_SC.pdf
Size:
458.7Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record