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dc.contributor.authorXu, Hongyan
dc.contributor.authorGeorge, Varghese
dc.date.accessioned2010-09-24T21:58:59Zen
dc.date.available2010-09-24T21:58:59Zen
dc.date.issued2008-05-09en_US
dc.identifier.citationBMC Proc. 2007 Dec 18; 1(Suppl 1):S32en_US
dc.identifier.issn1753-6561en_US
dc.identifier.pmid18466530en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/89en
dc.description.abstractFamily-based association approaches such as the transmission-disequilibrium test (TDT) are used extensively in the study of genetic traits because they are generally robust to the presence of population structure. However, these approaches necessarily involve recruitment of families, which is more costly and time-consuming than sampling unrelated individuals in the population-based approaches. Therefore, a family-based approach, which has high power, would be appealing because of the gain in time and cost due to the reduced sample size that is required to attain adequate power. Here we introduce a new family-based transmission test using the joint transmission status from affected sib pairs. We show that by including the transmission status of both siblings, our method gives higher power than the TDT design, while maintaining the correct type I error rate. We use the simulated data from affected sib-pair families with rheumatoid arthritis provided by Genetic Analysis Workshop 15 to illustrate our approach.
dc.rightsThe PMC Open Access Subset is a relatively small part of the total collection of articles in PMC. Articles in the PMC Open Access Subset are still protected by copyright, but are made available under a Creative Commons or similar license that generally allows more liberal redistribution and reuse than a traditional copyrighted work. Please refer to the license statement in each article for specific terms of use. The license terms are not identical for all articles in this subset.en_US
dc.titleA new transmission test for affected sib-pair families.en_US
dc.typeJournal Articleen_US
dc.identifier.pmcidPMC2367567en_US
dc.contributor.corporatenameDepartment of Biostatistics and Epidemiologyen_US
refterms.dateFOA2019-04-10T01:03:17Z
html.description.abstractFamily-based association approaches such as the transmission-disequilibrium test (TDT) are used extensively in the study of genetic traits because they are generally robust to the presence of population structure. However, these approaches necessarily involve recruitment of families, which is more costly and time-consuming than sampling unrelated individuals in the population-based approaches. Therefore, a family-based approach, which has high power, would be appealing because of the gain in time and cost due to the reduced sample size that is required to attain adequate power. Here we introduce a new family-based transmission test using the joint transmission status from affected sib pairs. We show that by including the transmission status of both siblings, our method gives higher power than the TDT design, while maintaining the correct type I error rate. We use the simulated data from affected sib-pair families with rheumatoid arthritis provided by Genetic Analysis Workshop 15 to illustrate our approach.


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