AbstractFamily-based association approaches such as the transmission-disequilibrium test (TDT) are used extensively in the study of genetic traits because they are generally robust to the presence of population structure. However, these approaches necessarily involve recruitment of families, which is more costly and time-consuming than sampling unrelated individuals in the population-based approaches. Therefore, a family-based approach, which has high power, would be appealing because of the gain in time and cost due to the reduced sample size that is required to attain adequate power. Here we introduce a new family-based transmission test using the joint transmission status from affected sib pairs. We show that by including the transmission status of both siblings, our method gives higher power than the TDT design, while maintaining the correct type I error rate. We use the simulated data from affected sib-pair families with rheumatoid arthritis provided by Genetic Analysis Workshop 15 to illustrate our approach.
CitationBMC Proc. 2007 Dec 18; 1(Suppl 1):S32
- Adaptive transmission disequilibrium test for family trio design.
- Authors: Yuan M, Tian X, Zheng G, Yang Y
- Issue date: 2009
- Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests.
- Authors: Li H, Hsu L
- Issue date: 2000 May
- Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test.
- Authors: Wicks J
- Issue date: 2000 Jun
- X-APL: an improved family-based test of association in the presence of linkage for the X chromosome.
- Authors: Chung RH, Morris RW, Zhang L, Li YJ, Martin ER
- Issue date: 2007 Jan
- Transmission disequilibrium test with discordant sib pairs when parents are available.
- Authors: Deng HW, Chen WM, Recker RR
- Issue date: 2002 May