• Effect of b-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content

      Jong, Chian Ju; Ito, Takashi; Mozaffari, Mahmood S.; Azuma, Junichi; Schaffer, Stephen W; Department of Oral Biology (2010-08-24)
      Background: The b-amino acid, taurine, is a nutritional requirement in some species. In these species, the depletion of intracellular stores of taurine leads to the development of severe organ dysfunction. The basis underlying these defects is poorly understood, although there is some suggestion that oxidative stress may contribute to the abnormalities. Recent studies indicate that taurine is required for normal mitochondrial protein synthesis and normal electron transport chain activity; it is known that defects in these events can lead to severe mitochondrial oxidative stress. The present study examines the effect of taurine deficiency on the first step of mitochondrial protein synthesis regulation by taurine, namely, the formation of taurinomethyluridine containing tRNA.