• High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy

      El-Asrar, Ahmed M. Abu; Nawaz, Mohd Imtiaz; Kangave, Dustan; Geboes, Karel; Ola, Mohammad Shamsul; Ahmad, Saif; Al-Shabrawey, Mohamed; Department of Oral Biology; Department of Ophthalmology (2011-07-06)
      Purpose: To measure levels of high-mobility group box −1 (HMGB1) and soluble receptor for advanced glycation end products (sRAGE) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate their levels with clinical disease activity and the levels of the inflammatory biomarkers monocyte chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-1β (IL-1β), and granulocyte macrophage colony-stimulating factor (GM-CSF). In addition, we examined the expression of HMGB1 in the retinas of diabetic mice.