• Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy

      Al-Shabrawey, Mohamed; Ahmad, Saif; Megyerdi, Sylvia; Othman, Amira; Baban, Babak; Palenski, Tammy L.; Shin, Eui Seok; Gurel, Zafer; Hsu, Stephen; Sheibani, Nader; et al. (2012-07-14)
      Purpose: The purpose of this study was to evaluate caspase-14 expression in the retina under normal and diabetic conditions, and to determine whether caspase-14 contributes to retinal microvascular cell death under high glucose conditions.
    • High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy

      El-Asrar, Ahmed M. Abu; Nawaz, Mohd Imtiaz; Kangave, Dustan; Geboes, Karel; Ola, Mohammad Shamsul; Ahmad, Saif; Al-Shabrawey, Mohamed; Department of Oral Biology; Department of Ophthalmology (2011-07-06)
      Purpose: To measure levels of high-mobility group box −1 (HMGB1) and soluble receptor for advanced glycation end products (sRAGE) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate their levels with clinical disease activity and the levels of the inflammatory biomarkers monocyte chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-1β (IL-1β), and granulocyte macrophage colony-stimulating factor (GM-CSF). In addition, we examined the expression of HMGB1 in the retinas of diabetic mice.
    • Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy

      Al-Shabrawey, Mohamed; Mussell, Rene; Kahook, Khalid; Tawfik, Amany; Eladl, Mohamed; Sarthy, Vijay; Nussbaum, Julian; El-Marakby, Ahmed; Park, Sun Young; Gurel, Zafer; et al. (2011-01-21)
      OBJECTIVE: Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migration. The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV).
    • Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers

      Al-Shabrawey, Mohamed; Smith, Sylvia B; Department of Oral Biology; Department of Ophthalmology; Vision Discovery Institute; Department of Cellular Biology and Anatomy (2010-03-23)
      Keywords: Diabetic retinopathy