• SHP-2 Promotes the Maturation of Oligodendrocyte Precursor Cells Through Akt and ERK1/2 Signaling In Vitro

      Liu, Xiujie; Li, Yuanyuan; Zhang, Yong; Lu, Yan; Guo, Wei; Liu, Peng; Zhou, Jiazhen; Xiang, Zhenghua; He, Cheng; Department of Neurology; et al. (2011-06-20)
      Background: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular mechanisms of maturation and myelination by oligodendrocytes remain elusive.