• Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

      Zhang, Quan-Guang; Laird, Melissa D; Han, Dong; Nguyen, Khoi; Scott, Erin L.; Dong, Yan; Dhandapani, Krishnan M.; Brann, Darrell W; Department of Neurology; Institute of Molecular Medicine and Genetics; et al. (2012-04-2)
      Background: Oxidative stress is known to play an important role in the pathology of traumatic brain injury. Mitochondria are thought to be the major source of the damaging reactive oxygen species (ROS) following TBI. However, recent work has revealed that the membrane, via the enzyme NADPH oxidase can also generate the superoxide radical (O2^-), and thereby potentially contribute to the oxidative stress following TBI. The current study thus addressed the potential role of NADPH oxidase in TBI.
    • Wnt proteins regulate acetylcholine receptor clustering in muscle cells

      Zhang, Bin; Liang, Chuan; Bates, Ryan; Yin, Yiming; Xiong, Wen-Cheng; Mei, Lin; Department of Neurology; Institute of Molecular Medicine and Genetics (2012-02-6)
      Background: The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses. NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing evidence indicates that Wnt signaling regulates NMJ formation in Drosophila, C. elegans and zebrafish.