• Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke

      Hoda, Md Nasrul; Li, Weiguo; Ahmad, Ajmal; Ogbi, Safia; Zemskova, Marina A; Johnson, Maribeth H.; Ergul, Adviye; Hill, William D; Hess, David C.; Sazonova, Irina Y; et al. (2011-12-16)
      Background: Minocycline provides neurovascular protection reducing acute cerebral injury. However, it is unclear whether minocycline is effective in females. We tested minocycline in both sexes and aged animals using a novel embolic stroke model in mice that closely mimics acute thromboembolic stroke in humans.