• Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans

      Keowkase, Roongpetch; Aboukhatwa, Marwa; Adam, Bao-Ling; Beach, J Warren; Terry, Alvin V.; Buccafusco, Jerry J; Luo, Yuan; Department of Pharmacology and Toxicology (2010-12-16)
      Background: Our previous work indicated that novel analogs of choline have cytoprotective effects in vitro that might be useful in neurodegenerative conditions such as Alzheimer's disease (AD). Furthermore, two lead compounds (JWB1-84-1 and JAY2-22-33) from a library of more than 50 improved cognitive performances in a transgenic mouse model of AD. The purpose of these experiments was to more specifically investigate the neuroprotective capabilities of these lead compounds both in vitro and in vivo.