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    An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties

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    Authors
    Gong, Shi-qiang
    Epasinghe, Jeevani
    Rueggeberg, Frederick A.
    Niu, Li-na
    Mettenberg, Donald
    Yiu, Cynthia K. Y.
    Blizzard, John D.
    Wu, Christine D.
    Mao, Jing
    Drisko, Connie L.
    Pashley, David H.
    Tay, Franklin R.
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    Issue Date
    2012-08-01
    URI
    http://hdl.handle.net/10675.2/817
    
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    Abstract
    Global increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.
    Citation
    PLoS One. 2012 Aug 1; 7(8):e42355
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0042355
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    Department of Oral Biology & Diagnostic Sciences: Faculty Research and Publications

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