• Effect of Metformin on Oral Implant Healing in Type 2 Diabetic Rats

      Inouye, Kimberly Ann; Department of Oral Biology (2011-04)
      In dentistry today, endosseous implants have become a generally favorable treatment option for edentulous spaces in the oral cavity because of proven biocompatibility, potential for esthetics, and good long term prognosis.(1) However, there are risk factors to consider that may affect and impair the osseointegration of an implant. A possible risk factor is type 2 diabetes mellitus (T2DM), a metabolic disorder characterized by insulin resistance at the target tissue site and progressive destruction of the pancreatic beta cells that ultimately results in prolonged periods of hyperglycemia.(2) When the serum glucose levels were persistently high, it was shown to impair bone metabolism and thus, has the potential to impair implant osseointegration.(3)