• Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy

      Al-Shabrawey, Mohamed; Ahmad, Saif; Megyerdi, Sylvia; Othman, Amira; Baban, Babak; Palenski, Tammy L.; Shin, Eui Seok; Gurel, Zafer; Hsu, Stephen; Sheibani, Nader; et al. (2012-07-14)
      Purpose: The purpose of this study was to evaluate caspase-14 expression in the retina under normal and diabetic conditions, and to determine whether caspase-14 contributes to retinal microvascular cell death under high glucose conditions.
    • Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy

      Al-Shabrawey, Mohamed; Mussell, Rene; Kahook, Khalid; Tawfik, Amany; Eladl, Mohamed; Sarthy, Vijay; Nussbaum, Julian; El-Marakby, Ahmed; Park, Sun Young; Gurel, Zafer; et al. (2011-01-21)
      OBJECTIVE: Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migration. The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV).