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dc.contributor.authorHoda, Md Nasrul
dc.contributor.authorLi, Weiguo
dc.contributor.authorAhmad, Ajmal
dc.contributor.authorOgbi, Safia
dc.contributor.authorZemskova, Marina A
dc.contributor.authorJohnson, Maribeth H.
dc.contributor.authorErgul, Adviye
dc.contributor.authorHill, William D
dc.contributor.authorHess, David C.
dc.contributor.authorSazonova, Irina Y
dc.date.accessioned2012-10-26T20:30:43Z
dc.date.available2012-10-26T20:30:43Z
dc.date.issued2011-12-16en_US
dc.identifier.citationExp Transl Stroke Med. 2011 Dec 16; 3:16en_US
dc.identifier.issn2040-7378en_US
dc.identifier.pmid22177314en_US
dc.identifier.doi10.1186/2040-7378-3-16en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/780
dc.description.abstractBackground: Minocycline provides neurovascular protection reducing acute cerebral injury. However, it is unclear whether minocycline is effective in females. We tested minocycline in both sexes and aged animals using a novel embolic stroke model in mice that closely mimics acute thromboembolic stroke in humans.
dc.description.abstractMethods: Five groups of mice were subjected to thromboembolic stroke: adult males, aged males, adult females, aged females, and adult ovariectomized females. They were treated with phosphate saline (vehicle) or minocycline (6 mg/kg) immediately after stroke onset. Behavioral outcomes, infarct volumes and cerebral blood flow were assessed. The effect of minocycline on expression and activity of MMP-9 was analyzed.
dc.description.abstractResults: The model resulted in reproducible infarct in the experimental groups. As expected, adult females were significantly more resistant to cerebral ischemic injury than males. This advantage was abolished by aging and ovariectomy. Minocycline significantly reduced the infarct volume (P < 0.0001) and also improved neurologic score (P < 0.0001) in all groups. Moreover, minocycline treatment significantly reduced mortality at 24 hours post stroke (P = 0.037) for aged mice (25% versus 54%). Stroke up-regulated MMP-9 level in the brain, and acute minocycline treatment reduced its expression in both genders (P < 0.0001).
dc.description.abstractConclusion: In a thromboembolic stroke model minocycline is neuroprotective irrespective of mouse sex and age.
dc.rightsCopyright ©2011 Hoda et al; licensee BioMed Central Ltd.en_US
dc.titleSex-independent neuroprotection with minocycline after experimental thromboembolic strokeen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3287111en_US
dc.contributor.corporatenameDepartment of Neurology
dc.contributor.corporatenameDepartment of Physiology
dc.contributor.corporatenameDepartment of Medicine
dc.contributor.corporatenameDepartment of Biostatistics and Epidemiology
dc.contributor.corporatenameDepartment of Cellular Biology and Anatomy
refterms.dateFOA2019-04-10T00:50:09Z
html.description.abstractBackground: Minocycline provides neurovascular protection reducing acute cerebral injury. However, it is unclear whether minocycline is effective in females. We tested minocycline in both sexes and aged animals using a novel embolic stroke model in mice that closely mimics acute thromboembolic stroke in humans.
html.description.abstractMethods: Five groups of mice were subjected to thromboembolic stroke: adult males, aged males, adult females, aged females, and adult ovariectomized females. They were treated with phosphate saline (vehicle) or minocycline (6 mg/kg) immediately after stroke onset. Behavioral outcomes, infarct volumes and cerebral blood flow were assessed. The effect of minocycline on expression and activity of MMP-9 was analyzed.
html.description.abstractResults: The model resulted in reproducible infarct in the experimental groups. As expected, adult females were significantly more resistant to cerebral ischemic injury than males. This advantage was abolished by aging and ovariectomy. Minocycline significantly reduced the infarct volume (P < 0.0001) and also improved neurologic score (P < 0.0001) in all groups. Moreover, minocycline treatment significantly reduced mortality at 24 hours post stroke (P = 0.037) for aged mice (25% versus 54%). Stroke up-regulated MMP-9 level in the brain, and acute minocycline treatment reduced its expression in both genders (P < 0.0001).
html.description.abstractConclusion: In a thromboembolic stroke model minocycline is neuroprotective irrespective of mouse sex and age.


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