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    Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects

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    Authors
    Ding, Zhi-Chun
    Zhou, Gang
    Issue Date
    2012-02-6
    URI
    http://hdl.handle.net/10675.2/779
    
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    Abstract
    Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy and immunotherapy for synergistic antitumor effects and improved clinical benefits. Findings from recent studies suggest that highly activated, polyfunctional CD4+ effector T cells have tremendous potential in strengthening and sustaining the overall host antitumor immunity in the postchemotherapy window. This review focuses on the latest progresses regarding the impact of chemotherapy on CD4+ T-cell phenotype and function and discusses the prospect of exploiting CD4+ T cells to control tumor progression and prevent relapse after chemotherapy.
    Citation
    Clin Dev Immunol. 2012 Feb 6; 2012:890178
    ae974a485f413a2113503eed53cd6c53
    10.1155/2012/890178
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    Georgia Cancer Center: Faculty Research and Presentations

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