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dc.contributor.authorUsuki, Seigo
dc.contributor.authorTsai, Ying-Ying
dc.contributor.authorMorikawa, Keiko
dc.contributor.authorNonaka, Shota
dc.contributor.authorOkuhara, Yasuhide
dc.contributor.authorKise, Mitsuo
dc.contributor.authorYu, Robert K.
dc.date.accessioned2012-10-26T20:30:42Z
dc.date.available2012-10-26T20:30:42Z
dc.date.issued2011-12-14en_US
dc.identifier.citationPLoS One. 2011 Dec 14; 6(12):e28693en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid22194889en_US
dc.identifier.doi10.1371/journal.pone.0028693en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/772
dc.description.abstractBackground: The pathology of diabetic neuropathy involves oxidative stress on pancreatic b-cells, and is related to decreased levels of Insulin-like growth factor 1 (IGF-1). Acylated steryl b-glucoside (PR-ASG) found in pre-germiated brown rice is a bioactive substance exhibiting properties that enhance activity of homocysteine-thiolactonase (HTase), reducing oxidative stress in diabetic neuropathy. The biological importance of PR-ASG in pancreatic b-cells remains unknown.
dc.description.abstractMethodology/Principal Findings: In the present study, a pre-germinated brown rice (PR)-diet was tested in streptozotocin (STZ)-induced diabetic rats. Compared with diabetic rats fed control diets, the PR-diet fed rats showed an improvement of serum metabolic and neurophysiological parameters. In addition, IGF-1 levels were found to be increased in the serum, liver, and pancreas of diabetic rats fed the PR-diet. The increased IGF-1 level in the pancreas led us to hypothesize that PR-ASG is protective for islet b-cells against the extensive injury of advanced or severe diabetes. Thus we examined PR-ASG to determine whether it showed anti-apoptotic, pro-proliferative effects on the insulin-secreting b-cells line, INS-1; and additionally, whether PR-ASG stimulated IGF-1 autocrine secretion/IGF-1-dependent glucose metabolism. We have demonstrated for the first time that PR-ASG increases IGF-1 production and secretion from pancreatic b-cells.
dc.description.abstractConclusion/Significance: These findings suggest that PR-ASG may affect pancreatic b-cells through the activation of an IGF- 1-dependent mechanism in the diabetic condition. Thus, intake of pre-germinated brown rice may have a beneficial effect in the treatment of diabetes, in particular diabetic neuropathy..
dc.rightsUsuki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectEndocrine Systemen_US
dc.subjectEndocrine Physiologyen_US
dc.subjectInsulin-like Growth Factoren_US
dc.subjectMedicineen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectEndocrine Systemen_US
dc.subjectEndocrine Physiologyen_US
dc.subjectInsulin-like Growth Factoren_US
dc.subjectClinical Geneticsen_US
dc.subjectMitochondrial Diseasesen_US
dc.subjectDiabetes Mellitus and Deafnessen_US
dc.subjectEndocrinologyen_US
dc.subjectDiabetic Endocrinologyen_US
dc.subjectDiabetes Mellitus Type 1en_US
dc.subjectDiabetes Mellitus Type 2en_US
dc.subjectEndocrine Physiologyen_US
dc.subjectInsulin-like Growth Factoren_US
dc.titleIGF-1 Induction by Acylated Steryl β-Glucosides Found in a Pre-Germinated Brown Rice Diet Reduces Oxidative Stress in Streptozotocin-Induced Diabetesen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3237479en_US
dc.contributor.corporatenameInstitute of Molecular Medicine and Genetics
refterms.dateFOA2019-04-10T00:49:20Z
html.description.abstractBackground: The pathology of diabetic neuropathy involves oxidative stress on pancreatic b-cells, and is related to decreased levels of Insulin-like growth factor 1 (IGF-1). Acylated steryl b-glucoside (PR-ASG) found in pre-germiated brown rice is a bioactive substance exhibiting properties that enhance activity of homocysteine-thiolactonase (HTase), reducing oxidative stress in diabetic neuropathy. The biological importance of PR-ASG in pancreatic b-cells remains unknown.
html.description.abstractMethodology/Principal Findings: In the present study, a pre-germinated brown rice (PR)-diet was tested in streptozotocin (STZ)-induced diabetic rats. Compared with diabetic rats fed control diets, the PR-diet fed rats showed an improvement of serum metabolic and neurophysiological parameters. In addition, IGF-1 levels were found to be increased in the serum, liver, and pancreas of diabetic rats fed the PR-diet. The increased IGF-1 level in the pancreas led us to hypothesize that PR-ASG is protective for islet b-cells against the extensive injury of advanced or severe diabetes. Thus we examined PR-ASG to determine whether it showed anti-apoptotic, pro-proliferative effects on the insulin-secreting b-cells line, INS-1; and additionally, whether PR-ASG stimulated IGF-1 autocrine secretion/IGF-1-dependent glucose metabolism. We have demonstrated for the first time that PR-ASG increases IGF-1 production and secretion from pancreatic b-cells.
html.description.abstractConclusion/Significance: These findings suggest that PR-ASG may affect pancreatic b-cells through the activation of an IGF- 1-dependent mechanism in the diabetic condition. Thus, intake of pre-germinated brown rice may have a beneficial effect in the treatment of diabetes, in particular diabetic neuropathy..


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