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dc.contributor.authorGregoski, Mathew J.
dc.contributor.authorBarnes, Vernon A.
dc.contributor.authorTingen, Martha S.
dc.contributor.authorDong, Yanbin
dc.contributor.authorZhu, Haidong
dc.contributor.authorTreiber, Frank A.
dc.date.accessioned2012-10-26T20:30:41Z
dc.date.available2012-10-26T20:30:41Z
dc.date.issued2011-11-24en_US
dc.identifier.citationInt J Hypertens. 2012 Nov 24; 2012:510291en_US
dc.identifier.issn2090-0392en_US
dc.identifier.pmid22164329en_US
dc.identifier.doi10.1155/2012/510291en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/769
dc.description.abstractStress-activated gene * environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.
dc.rightsCopyright © 2012 Mathew J. Gregoski et al.en_US
dc.subjectResearch Articleen_US
dc.titleDifferential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposureen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3227499en_US
dc.contributor.corporatenameGeorgia Institute for Prevention of Human Diseases and Accidents
dc.contributor.corporatenameDepartment of Pediatrics
refterms.dateFOA2019-04-10T00:48:56Z
html.description.abstractStress-activated gene * environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.


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