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    Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

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    Authors
    Mi, Xiaofan
    He, Hongzhi
    Deng, Yangxin
    Levin, Abert M
    She, Jin-Xiong
    Mi, Qing-Sheng
    Zhou, Li
    Issue Date
    2011-10-20
    URI
    http://hdl.handle.net/10675.2/767
    
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    Abstract
    MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.
    Citation
    Diabetol Metab Syndr. 2011 Oct 20; 3:27
    ae974a485f413a2113503eed53cd6c53
    10.1186/1758-5996-3-27
    Scopus Count
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    Center for Biotechnology and Genomic Medicine: Faculty Research and Presentations

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