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    The Role of Uridine Adenosine Tetraphosphate in the Vascular System

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    Authors
    Matsumoto, Takayuki
    Tostes, Rita C.
    Webb, R. Clinton
    Issue Date
    2011-11-1
    URI
    http://hdl.handle.net/10675.2/765
    
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    Abstract
    The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.
    Citation
    Adv Pharmacol Sci. 2011 Nov 1; 2011:435132
    ae974a485f413a2113503eed53cd6c53
    10.1155/2011/435132
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    Department of Physiology: Faculty Research and Presentations

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