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    Loss of Zebrafish lgi1b Leads to Hydrocephalus and Sensitization to Pentylenetetrazol Induced Seizure-Like Behavior

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    Authors
    Teng, Yong
    Xie, Xiayang
    Walker, Steven L.
    Saxena, Meera T.
    Kozlowski, David J.
    Mumm, Jeff S.
    Cowell, John K.
    Issue Date
    2011-09-16
    URI
    http://hdl.handle.net/10675.2/764
    
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    Abstract
    Mutations in the LGI1 gene predispose to a hereditary epilepsy syndrome and is the first gene associated with this disease which does not encode an ion channel protein. In zebrafish, there are two paralogs of the LGI1 gene, lgi1a and lgi1b. Knockdown of lgi1a results in a seizure-like hyperactivity phenotype with associated developmental abnormalities characterized by cellular loss in the eyes and brain. We have now generated knockdown morphants for the lgi1b gene which also show developmental abnormalities but do not show a seizure-like behavior. Instead, the most striking phenotype involves significant enlargement of the ventricles (hydrocephalus). As shown for the lgi1a morphants, however, lgi1b morphants are also sensitized to PTZ-induced hyperactivity. The different phenotypes between the two lgi1 morphants support a subfunctionalization model for the two paralogs.
    Citation
    PLoS One. 2011 Sep 16; 6(9):e24596
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0024596
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    Georgia Cancer Center: Faculty Research and Presentations

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