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    Carcinomatous Meningitis: The Natural History of Successfully Treated Metastatic Bladder Cancer

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    Authors
    Tadepalli, S.
    Coleman, Teresa
    Hackett, Ladawn A.
    Liles, G.B.
    Issue Date
    2011-08-24
    URI
    http://hdl.handle.net/10675.2/757
    
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    Abstract
    Carcinomatous meningitis due to bladder cancer is a rare entity reported only in case reports. Optimal therapy is thus poorly defined with earlier cases reporting an unsuccessful outcome. Here we report a case of late carcinomatous meningitis secondary to transitional cell carcinoma (TCC) of the bladder occurring in a patient in complete remission. He was successfully treated with intrathecal methotrexate and whole brain irradiation and experienced prolonged survival after treatment. With modern chemotherapy increasing complete remissions and survival rates in patients with TCC, more and more patients are being reported with carcinomatous meningitis. We raise the question of whether central nervous system prophylaxis should be considered in patients with TCC achieving a complete remission to chemotherapy in the metastatic setting.
    Key words: Carcinomatous meningitis
    Citation
    Case Rep Oncol. 2011 Aug 24; 4(2):406-412
    ae974a485f413a2113503eed53cd6c53
    10.1159/000331263
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