• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Physiology
    • Department of Physiology: Faculty Research and Presentations
    • View Item
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Physiology
    • Department of Physiology: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Cortical gene transcription response patterns to water maze training in aged mice

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    1471-2202-12-63.pdf
    Size:
    2.386Mb
    Format:
    PDF
    Download
    Authors
    Park, Sung-Soo
    Stranahan, Alexis M.
    Chadwick, Wayne
    Zhou, Yu
    Wang, Liyun
    Martin, Bronwen
    Becker, Kevin G.
    Maudsley, Stuart
    Issue Date
    2011-06-29
    URI
    http://hdl.handle.net/10675.2/752
    
    Metadata
    Show full item record
    Abstract
    Background: The hippocampus mediates the acquisition of spatial memory, but the memory trace is eventually transferred to the cortex. We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training.
    Results: We identified genes that were differentially responsive in aged mice with accurate spatial performance during probe trials or repeated swimming sessions, relative to home cage conditions. Effective learners exhibited significantly greater activation of several pathways, such as the mitogen-activated protein kinase and insulin receptor signaling pathways, relative to swimmers. The genes encoding activity-related cytoskeletal protein (Arc) and brain-derived neurotrophic factor (BDNF) were upregulated in proficient learners, relative to swimmers and home cage controls, while the gene encoding Rho GTPase activating protein 32 (GRIT) was downregulated. We explored the regulation of Arc, BDNF, and GRIT expression in greater morphological detail using in situ hybridization. Recall during probe trials enhanced Arc expression across multiple cortical regions involved in the cognitive component of water maze learning, while BDNF expression was more homogeneously upregulated across cortical regions involved in the associational and sensorimotor aspects of water maze training. In contrast, levels of GRIT expression were uniformly reduced across all cortical regions examined.
    Conclusions: These results suggest that cortical gene transcription is responsive to learning in aged mice that exhibit behavioral proficiency, and support a distributed hypothesis of memory storage across multiple cortical compartments.
    Citation
    BMC Neurosci. 2011 Jun 29; 12:63
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2202-12-63
    Scopus Count
    Collections
    Department of Physiology: Faculty Research and Presentations

    entitlement

    Related articles

    • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.
    • Authors: McDowell KA, Hutchinson AN, Wong-Goodrich SJ, Presby MM, Su D, Rodriguiz RM, Law KC, Williams CL, Wetsel WC, West AE
    • Issue date: 2010 Jun 2
    • Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268.
    • Authors: Guzowski JF, Setlow B, Wagner EK, McGaugh JL
    • Issue date: 2001 Jul 15
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.
    • Authors: Vaynman S, Ying Z, Gomez-Pinilla F
    • Issue date: 2004 Nov
    • Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats.
    • Authors: Silhol M, Arancibia S, Maurice T, Tapia-Arancibia L
    • Issue date: 2007 May 25
    • Amygdala electrical stimulation inducing spatial memory recovery produces an increase of hippocampal bdnf and arc gene expression.
    • Authors: Mercerón-Martínez D, Almaguer-Melian W, Alberti-Amador E, Estupiñán B, Fernández I, Bergado JA
    • Issue date: 2016 Jun
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.