• Login
    View Item 
    •   Home
    • Centers & Institutes
    • Vascular Biology Center
    • Vascular Biology Center: Faculty Research and Publication
    • View Item
    •   Home
    • Centers & Institutes
    • Vascular Biology Center
    • Vascular Biology Center: Faculty Research and Publication
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    1471-2202-6-49.pdf
    Size:
    392.0Kb
    Format:
    PDF
    Download
    Authors
    Harris, Alex K
    Ergul, Adviye
    Kozak, Anna
    Machado, Livia S
    Johnson, Maribeth H.
    Fagan, Susan C.
    Issue Date
    2005-08-25
    URI
    http://hdl.handle.net/10675.2/75
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown. RESULTS: Anti-PMN treatment caused successful depletion of neutrophils in treated animals. There was no difference in either infarct volume or hemorrhage between control and PMN depleted animals. While there were significant increases in gelatinase (MMP-2 and MMP-9) expression and activity and edema formation associated with ischemia, neutrophil depletion failed to cause any change. CONCLUSION: The main finding of this study is that, in the absence of circulating neutrophils, MMP-2 and MMP-9 expression and activity are still up-regulated following focal cerebral ischemia. Additionally, neutrophil depletion had no influence on indicators of ischemic brain damage including edema, hemorrhage, and infarct size. These findings indicate that, at least acutely, neutrophils are not a significant contributor of gelatinase activity associated with acute neurovascular damage after stroke.
    Citation
    BMC Neurosci. 2005 Aug 3; 6:49
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2202-6-49
    Scopus Count
    Collections
    Vascular Biology Center: Faculty Research and Publication

    entitlement

    Related articles

    • Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation.
    • Authors: del Zoppo GJ, Frankowski H, Gu YH, Osada T, Kanazawa M, Milner R, Wang X, Hosomi N, Mabuchi T, Koziol JA
    • Issue date: 2012 May
    • Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats.
    • Authors: Justicia C, Panés J, Solé S, Cervera A, Deulofeu R, Chamorro A, Planas AM
    • Issue date: 2003 Dec
    • Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
    • Authors: Hosomi N, Ban CR, Naya T, Takahashi T, Guo P, Song XY, Kohno M
    • Issue date: 2005 Aug
    • Reduced brain edema and matrix metalloproteinase (MMP) expression by pre-reperfusion infusion into ischemic territory in rat.
    • Authors: Ding YH, Li J, Rafols JA, Ding Y
    • Issue date: 2004 Nov 30
    • Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke.
    • Authors: Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J
    • Issue date: 2006 Jun
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.