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    Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine

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    Authors
    Kuang, Hui
    Lin, Longnian
    Tsien, Joe Z.
    Issue Date
    2010-12-8
    URI
    http://hdl.handle.net/10675.2/730
    
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    Abstract
    Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.
    Citation
    PLoS One. 2010 Dec 8; 5(12):e15209
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0015209
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