Temporal Dynamics of Distinct CA1 Cell Populations during Unconscious State Induced by Ketamine
AbstractKetamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.
CitationPLoS One. 2010 Dec 8; 5(12):e15209
- Distinct retrosplenial cortex cell populations and their spike dynamics during ketamine-induced unconscious state.
- Authors: Fox GE, Li M, Zhao F, Tsien JZ
- Issue date: 2017
- Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo.
- Authors: Klausberger T, Magill PJ, Márton LF, Roberts JD, Cobden PM, Buzsáki G, Somogyi P
- Issue date: 2003 Feb 20
- Consistent sequential activity across diverse forms of UP states under ketamine anesthesia.
- Authors: Luczak A, Barthó P
- Issue date: 2012 Sep
- Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.
- Authors: Ribeiro PO, Tomé AR, Silva HB, Cunha RA, Antunes LM
- Issue date: 2014 Apr 29
- Excitatory inputs to CA1 interneurons show selective synaptic dynamics.
- Authors: Wierenga CJ, Wadman WJ
- Issue date: 2003 Aug