Show simple item record

dc.contributor.authorPillai, Anilkumar*
dc.contributor.authorBruno, Davide*
dc.contributor.authorSarreal, Antero S.*
dc.contributor.authorHernando, Raymundo T.*
dc.contributor.authorSaint-Louis, Leslie A.*
dc.contributor.authorNierenberg, Jay*
dc.contributor.authorGinsberg, Stephen D.*
dc.contributor.authorPomara, Nunzio*
dc.contributor.authorMehta, Pankaj D.*
dc.contributor.authorZetterberg, Henrik*
dc.contributor.authorBlennow, Kaj*
dc.contributor.authorBuckley, Peter F.*
dc.date.accessioned2012-10-26T16:40:52Z
dc.date.available2012-10-26T16:40:52Z
dc.date.issued2012-07-2en_US
dc.identifier.citationPLoS One. 2012 Jul 2; 7(7):e39358en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid22768299en_US
dc.identifier.doi10.1371/journal.pone.0039358en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/716
dc.description.abstractBrain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression as well as neuropsychiatric and neurodegenerative disorders. Recent studies show a role of BDNF in energy metabolism and body weight regulation. We examined BDNF levels in plasma and cerebrospinal fluid (CSF) samples from age matched elderly depressed and control subjects. Also, the association of BDNF levels with age, gender, body weight, body mass index (BMI), and cognitive performance was evaluated. We did not find any significant differences in plasma and CSF BDNF levels between depressed and control subjects. Plasma BDNF levels were negatively correlated with age (but not with BMI and body weight), when analyses were performed including both depressed and control subjects. A significant reduction in plasma BDNF levels was observed in females as compared to male subjects, and the change in BDNF levels were significantly and positively related to body weight in females. Furthermore, significant increases in Total Recall and Delayed Recall values were found in females as compared to males. In conclusion, the lower BDNF levels observed in females suggest that changes in peripheral BDNF levels are likely secondary to an altered energy balance. However, further studies using larger sample size are warranted.
dc.rightsPillai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectEndocrine Systemen_US
dc.subjectEndocrine Physiologyen_US
dc.subjectGrowth Factorsen_US
dc.subjectBiochemistryen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectNerve Growth Factoren_US
dc.subjectProteinsen_US
dc.subjectGrowth Factorsen_US
dc.subjectNeuroscienceen_US
dc.subjectNeurochemistryen_US
dc.subjectNeurochemicalsen_US
dc.subjectNerve Growth Factoren_US
dc.subjectMedicineen_US
dc.subjectEndocrinologyen_US
dc.subjectEndocrine Physiologyen_US
dc.subjectGrowth Factorsen_US
dc.subjectGeriatricsen_US
dc.subjectMental Healthen_US
dc.subjectPsychiatryen_US
dc.subjectAnxiety Disordersen_US
dc.subjectDementiaen_US
dc.subjectMood Disordersen_US
dc.subjectNeuropsychiatric Disordersen_US
dc.titlePlasma BDNF Levels Vary in Relation to Body Weight in Femalesen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3388065en_US
dc.contributor.corporatenameDepartment of Psychiatry and Health Behavior
refterms.dateFOA2019-04-10T00:39:45Z
html.description.abstractBrain derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression as well as neuropsychiatric and neurodegenerative disorders. Recent studies show a role of BDNF in energy metabolism and body weight regulation. We examined BDNF levels in plasma and cerebrospinal fluid (CSF) samples from age matched elderly depressed and control subjects. Also, the association of BDNF levels with age, gender, body weight, body mass index (BMI), and cognitive performance was evaluated. We did not find any significant differences in plasma and CSF BDNF levels between depressed and control subjects. Plasma BDNF levels were negatively correlated with age (but not with BMI and body weight), when analyses were performed including both depressed and control subjects. A significant reduction in plasma BDNF levels was observed in females as compared to male subjects, and the change in BDNF levels were significantly and positively related to body weight in females. Furthermore, significant increases in Total Recall and Delayed Recall values were found in females as compared to males. In conclusion, the lower BDNF levels observed in females suggest that changes in peripheral BDNF levels are likely secondary to an altered energy balance. However, further studies using larger sample size are warranted.


Files in this item

Thumbnail
Name:
pone.0039358.pdf
Size:
134.5Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record