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    Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In Vivo

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    Authors
    Demidova-Rice, Tatiana N.
    Wolf, Lindsey
    Deckenback, Jeffry
    Hamblin, Michael R.
    Herman, Ira M.
    Issue Date
    2012-02-23
    URI
    http://hdl.handle.net/10675.2/696
    
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    Abstract
    Previous work in our laboratory has described several pro-angiogenic short peptides derived from endothelial extracellular matrices degraded by bacterial collagenase. Here we tested whether these peptides could stimulate wound healing in vivo. Our experiments demonstrated that a peptide created as combination of fragments of tenascin X and fibrillin 1 (comb1) applied into cranial dermal wounds created in mice treated with cyclophosphamide to impair wound healing, can improve the rate of wound closure. Furthermore, we identify and characterize a novel peptide (UN3) created and modified from two naturally-occurring peptides, which are present in human platelet-rich plasma. In vitro testing of UN3 demonstrates that it causes a 50% increase in endothelial proliferation, 250% increase in angiogenic response and a tripling of epithelial cell migration in response to injury.
    Citation
    PLoS One. 2012 Feb 23; 7(2):e32146
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0032146
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    Department of Cellular Biology and Anatomy: Faculty Research and Presentations

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