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    Antimycotic Ciclopirox Olamine in the Diabetic Environment Promotes Angiogenesis and Enhances Wound Healing

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    Authors
    Ko, Sae Hee
    Nauta, Allison
    Morrison, Shane D.
    Zhou, Hongyan
    Zimmermann, Andrew
    Gurtner, Geoffrey C.
    Ding, Sheng
    Longaker, Michael T.
    Issue Date
    2011-11-18
    URI
    http://hdl.handle.net/10675.2/685
    
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    Abstract
    Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vitro led to upregulation of multiple angiogenic genes and increased availability of HIF-1α. Using an excisional wound splinting model in diabetic mice, we showed that serial topical treatment with CPX enhanced wound healing compared to vehicle control treatment, with significantly accelerated wound closure, increased angiogenesis, and increased dermal cellularity. These findings offer a promising new topical pharmacologic therapy for the treatment of diabetic wounds.
    Citation
    PLoS One. 2011 Nov 18; 6(11):e27844
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0027844
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