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    Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

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    Authors
    VanValkenburgh, Jeffrey
    Albu, Diana I.
    Bapanpally, Chandra
    Casanova, Sarah
    Califano, Danielle
    Jones, David M.
    Ignatowicz, Leszek
    Kawamoto, Shimpei
    Fagarasan, Sidonia
    Jenkins, Nancy A.
    Copeland, Neal G.
    Liu, Pentao
    Avram, Dorina
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    Issue Date
    2011-09-26
    URI
    http://hdl.handle.net/10675.2/678
    
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    Abstract
    Dysregulated CD4+ T cell responses and alterations in T regulatory cells (Treg cells) play a critical role in autoimmune diseases, including inflammatory bowel disease (IBD). The current study demonstrates that removal of Bcl11b at the double-positive stage of T cell development or only in Treg cells causes IBD because of proinflammatory cytokine-producing CD4+ T cells infiltrating the colon. Provision of WT Treg cells prevented IBD, demonstrating that alterations in Treg cells are responsible for the disease. Furthermore, Bcl11b-deficient Treg cells had reduced suppressor activity with altered gene expression profiles, including reduced expression of the genes encoding Foxp3 and IL-10, and up-regulation of genes encoding proinflammatory cytokines. Additionally, the absence of Bcl11b altered the induction of Foxp3 expression and reduced the generation of induced Treg cells (iTreg cells) after Tgf-b treatment of conventional CD4+ T cells. Bcl11b bound to Foxp3 and IL-10 promoters, as well as to critical conserved noncoding sequences within the Foxp3 and IL-10 loci, and mutating the Bcl11b binding site in the Foxp3 promoter reduced expression of a luciferase reporter gene. These experiments demonstrate that Bcl11b is indispensable for Treg suppressor function and for maintenance of optimal Foxp3 and IL-10 gene expression, as well as for the induction of Foxp3 expression in conventional CD4+ T cells in response to Tgf-b and generation of iTreg cells.
    Citation
    J Exp Med. 2011 Sep 26; 208(10):2069-2081
    ae974a485f413a2113503eed53cd6c53
    10.1084/jem.20102683
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