P2Y receptors as regulators of lung endothelial barrier integrity
MetadataShow full item record
AbstractEndothelial cells (ECs), forming a semi-permeable barrier between the interior space of blood vessels and underlying tissues, control such diverse processes as vascular tone, homeostasis, adhesion of platelets, and leukocytes to the vascular wall and permeability of vascular wall for cells and fluids. Mechanisms which govern the highly clinically relevant process of increased EC permeability are under intense investigation. It is well known that loss of this barrier (permeability increase) results in tissue inflammation, the hall mark of inflammatory diseases such as acute lung injury and its severe form, acute respiratory distress syndrome. Little is known about processes which determine the endothelial barrier enhancement or protection against permeability increase. It is now well accepted that extracellular purines and pyrimidines are promising and physiologically relevant barrier-protective agents and their effects are mediated by interaction with cell surface P2Y receptors which belong to the superfamily of G-protein-coupled receptors. The therapeutic potential of P2Y receptors is rapidly expanding field in pharmacology and some selective agonists became recently available. Here, we present an overview of recently identified P2Y receptor agonists that enhance the pulmonary endothelial barrier and inhibit and/or reverse endothelial barrier disruption.
CitationJ Cardiovasc Dis Res. 2011 Jan-Mar; 2(1):14-22
- Cytoskeletal mechanisms regulating vascular endothelial barrier function in response to acute lung injury.
- Authors: Kása A, Csortos C, Verin AD
- Issue date: 2015
- Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation.
- Authors: Fan Q, Mao H, Xie L, Pi X
- Issue date: 2019 Jan
- Molecular mechanisms in lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.
- Authors: Liu H, Yu X, Yu S, Kou J
- Issue date: 2015 Dec
- miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability.
- Authors: Siddiqui MR, Akhtar S, Shahid M, Tauseef M, McDonough K, Shanley TP
- Issue date: 2019 Aug
- Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement.
- Authors: Umapathy NS, Zemskov EA, Gonzales J, Gorshkov BA, Sridhar S, Chakraborty T, Lucas R, Verin AD
- Issue date: 2010 Apr