Show simple item record

dc.contributor.authorLiu, Xiujie
dc.contributor.authorLi, Yuanyuan
dc.contributor.authorZhang, Yong
dc.contributor.authorLu, Yan
dc.contributor.authorGuo, Wei
dc.contributor.authorLiu, Peng
dc.contributor.authorZhou, Jiazhen
dc.contributor.authorXiang, Zhenghua
dc.contributor.authorHe, Cheng
dc.date.accessioned2012-10-26T16:27:00Z
dc.date.available2012-10-26T16:27:00Z
dc.date.issued2011-06-20en_US
dc.identifier.citationPLoS One. 2011 Jun 20; 6(6):e21058en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid21701583en_US
dc.identifier.doi10.1371/journal.pone.0021058en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/658
dc.description.abstractBackground: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular mechanisms of maturation and myelination by oligodendrocytes remain elusive.
dc.description.abstractMethods and Findings: In the present study, we showed that maturation of oligodendrocytes was attenuated by sodium orthovanadate (a comprehensive inhibitor of tyrosine phosphatases) and PTPi IV (a specific inhibitor of SHP-2). It is also found that SHP-2 was persistently expressed during maturation process of OPCs. Down-regulation of endogenous SHP-2 led to impairment of oligodendrocytes maturation and this effect was triiodo-L-thyronine (T3) dependent. Furthermore, over-expression of SHP-2 was shown to promote maturation of oligodendrocytes. Finally, it has been identified that SHP-2 was involved in activation of Akt and extracellular-regulated kinases 1 and 2 (ERK1/2) induced by T3 in oligodendrocytes.
dc.description.abstractConclusions: SHP-2 promotes oligodendrocytes maturation via Akt and ERK1/2 signaling in vitro.
dc.rightsLiu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectCell Differentiationen_US
dc.subjectCell Fate Determinationen_US
dc.subjectMolecular Cell Biologyen_US
dc.subjectSignal Transductionen_US
dc.subjectSignaling Cascadesen_US
dc.subjectAkt Signaling Cascadeen_US
dc.subjectERK signaling cascadeen_US
dc.subjectNeuroscienceen_US
dc.subjectCellular Neuroscienceen_US
dc.subjectNeuronal Morphologyen_US
dc.subjectDevelopmental Neuroscienceen_US
dc.subjectNeuroglial Developmenten_US
dc.subjectMolecular Neuroscienceen_US
dc.subjectSignaling Pathwaysen_US
dc.titleSHP-2 Promotes the Maturation of Oligodendrocyte Precursor Cells Through Akt and ERK1/2 Signaling In Vitroen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3118803en_US
dc.contributor.corporatenameDepartment of Neurology
dc.contributor.corporatenameCollege of Graduate Studies
refterms.dateFOA2019-04-10T00:28:37Z
html.description.abstractBackground: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular mechanisms of maturation and myelination by oligodendrocytes remain elusive.
html.description.abstractMethods and Findings: In the present study, we showed that maturation of oligodendrocytes was attenuated by sodium orthovanadate (a comprehensive inhibitor of tyrosine phosphatases) and PTPi IV (a specific inhibitor of SHP-2). It is also found that SHP-2 was persistently expressed during maturation process of OPCs. Down-regulation of endogenous SHP-2 led to impairment of oligodendrocytes maturation and this effect was triiodo-L-thyronine (T3) dependent. Furthermore, over-expression of SHP-2 was shown to promote maturation of oligodendrocytes. Finally, it has been identified that SHP-2 was involved in activation of Akt and extracellular-regulated kinases 1 and 2 (ERK1/2) induced by T3 in oligodendrocytes.
html.description.abstractConclusions: SHP-2 promotes oligodendrocytes maturation via Akt and ERK1/2 signaling in vitro.


Files in this item

Thumbnail
Name:
pone.0021058.pdf
Size:
3.032Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record