• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    pone.0018350.pdf
    Size:
    259.7Kb
    Format:
    PDF
    Download
    Authors
    Przybycien-Szymanska, Magdalena M.
    Mott, Natasha N.
    Paul, Caitlin R.
    Gillespie, Roberta A.
    Pak, Toni R.
    Issue Date
    2011-04-13
    URI
    http://hdl.handle.net/10675.2/650
    
    Metadata
    Show full item record
    Abstract
    Adolescence is a dynamic and important period of brain development however, little is known about the long-term neurobiological consequences of alcohol consumption during puberty. Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period. Thus, the primary goal of this study was to determine whether these observed changes in important central regulators of the stress response were permanent or transient. In this study, juvenile male Wistar rats were treated with a binge-pattern EtOH treatment paradigm or saline alone for 8 days. The animals were left undisturbed until adulthood when they received a second round of treatments consisting of saline alone, a single dose of EtOH, or a second binge-pattern treatment paradigm. The results showed that pubertal binge-pattern EtOH exposure induced striking long-lasting alterations of many HPA axis parameters. Overall, our data provide strong evidence that binge-pattern EtOH exposure during pubertal maturation has long-term detrimental effects for the healthy development of the HPA axis.
    Citation
    PLoS One. 2011 Apr 13; 6(4):e18350
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0018350
    Scopus Count
    Collections
    Department of Neurology: Faculty Research and Presentations

    entitlement

    Related articles

    • Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis.
    • Authors: Przybycien-Szymanska MM, Rao YS, Pak TR
    • Issue date: 2010 Feb
    • 17β-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence.
    • Authors: Przybycien-Szymanska MM, Gillespie RA, Pak TR
    • Issue date: 2012
    • Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes.
    • Authors: Yi SS, Hwang IK, Shin JH, Choi JH, Lee CH, Kim IY, Kim YN, Won MH, Park IS, Seong JK, Yoon YS
    • Issue date: 2010 Oct
    • The hypothalamo-pituitary-adrenal axis response to experimental traumatic brain injury.
    • Authors: Grundy PL, Harbuz MS, Jessop DS, Lightman SL, Sharples PM
    • Issue date: 2001 Dec
    • Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis.
    • Authors: Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW
    • Issue date: 2000 Dec
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.