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    Chemokine (C-C Motif) Ligand 2 (CCL2) in Sera of Patients with Type 1 Diabetes and Diabetic Complications

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    Authors
    Guan, Ruili
    Purohit, Sharad
    Wang, Hongjie
    Bode, Bruce
    Reed, John Chip
    Steed, R. Dennis
    Anderson, Stephen W.
    Steed, Leigh
    Hopkins, Diane
    Xia, Chun
    She, Jin-Xiong
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    Issue Date
    2011-04-12
    URI
    http://hdl.handle.net/10675.2/648
    
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    Abstract
    Background: Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive and inconsistent.
    Methods: In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay.
    Results: Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact on serum MCP-1 levels in either healthy controls or patients. While hemoglobin A1c levels did not have a major influence on serum MCP-1 levels, the mean serum MCP-1 levels are significantly higher in patients with multiple complications (mean=242 ng/ml) compared to patients without any complications (mean=201 ng/ml) (p=3.5x10^-6). Furthermore, mean serum MCP-1 is higher in controls (mean=261 ng/ml) than T1D patients (mean=208 ng/ml) (p<10^-23). More importantly, the frequency of subjects with extremely high levels (>99th percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the T1D group compared to the control group (odds ratio=0.11, p<10^-33).
    Conclusion: MCP-1 may have a dual role in T1D and its complications. While very high levels of serum MCP-1 may be protective against the development of T1D, complications are associated with higher serum MCP-1 levels within the T1D group.
    Citation
    PLoS One. 2011 Apr 12; 6(4):e17822
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0017822
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