• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    HER2 Targeted Molecular MR Imaging Using a De Novo Designed Protein Contrast Agent

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    pone.0018103.pdf
    Size:
    4.451Mb
    Format:
    PDF
    Download
    Authors
    Qiao, Jingjuan
    Li, Shunyi
    Wei, Lixia
    Jiang, Jie
    Long, Robert
    Mao, Hui
    Wei, Ling
    Wang, Liya
    Yang, Hua
    Grossniklaus, Hans E.
    Liu, Zhi-Ren
    Yang, Jenny J.
    Show allShow less
    Issue Date
    2011-03-24
    URI
    http://hdl.handle.net/10675.2/643
    
    Metadata
    Show full item record
    Abstract
    The application of magnetic resonance imaging (MRI) to non-invasively assess disease biomarkers has been hampered by the lack of desired contrast agents with high relaxivity, targeting capability, and optimized pharmacokinetics. We have developed a novel MR imaging probe targeting to HER2, a biomarker for various cancer types and a drug target for anti-cancer therapies. This multimodal HER20targeted MR imaging probe integrates a de novo designed protein contrast agent with a high affinity HER2 affibody and a near IR fluorescent dye. Our probe can differentially monitor tumors with different expression levels of HER2 in both human cell lines and xenograft mice models. In addition to its 100-fold higher dose efficiency compared to clinically approved non-targeting contrast agent DTPA, our developed agent also exhibits advantages in crossing the endothelial boundary, tissue distribution, and tumor tissue retention over reported contrast agents as demonstrated by even distribution of the imaging probe across the entire tumor mass. This contrast agent will provide a powerful tool for quantitative assessment of molecular markers, and improved resolution for diagnosis, prognosis and drug discovery.
    Citation
    PLoS One. 2011 Mar 24; 6(3):e18103
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0018103
    Scopus Count
    Collections
    Department of Neurology: Faculty Research and Presentations

    entitlement

    Related articles

    • Targeted tumor MRI with gadobutrol-loaded anti-HER2 immunoliposomes.
    • Authors: Chen W, Liu B, Chen J, Liu G, Liu X
    • Issue date: 2017 May
    • Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents.
    • Authors: Qiao J, Xue S, Pu F, White N, Jiang J, Liu ZR, Yang JJ
    • Issue date: 2014 Feb
    • A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer.
    • Authors: Lv W, Shen Y, Yang H, Yang R, Cai W, Zhang J, Yuan L, Duan Y, Zhang L
    • Issue date: 2018
    • In Vivo HER2-Targeted Magnetic Resonance Tumor Imaging Using Iron Oxide Nanoparticles Conjugated with Anti-HER2 Fragment Antibody.
    • Authors: Ding N, Sano K, Kanazaki K, Ohashi M, Deguchi J, Kanada Y, Ono M, Saji H
    • Issue date: 2016 Dec
    • Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging.
    • Authors: Kanazaki K, Sano K, Makino A, Shimizu Y, Yamauchi F, Ogawa S, Ding N, Yano T, Temma T, Ono M, Saji H
    • Issue date: 2015 Nov
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.