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    Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal Population

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    Authors
    Wang, Dong V.
    Tsien, Joe Z.
    Issue Date
    2011-01-27
    URI
    http://hdl.handle.net/10675.2/630
    
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    Abstract
    The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.
    Citation
    PLoS One. 2011 Jan 27; 6(1):e16528
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0016528
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    Brain & Behavior Discovery Institute: Faculty Research and Presentations

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