Show simple item record

dc.contributor.authorYao, Lin
dc.contributor.authorRomero, Maritza J.
dc.contributor.authorToque, Haroldo A.
dc.contributor.authorYang, Guang
dc.contributor.authorCaldwell, Ruth B.
dc.contributor.authorCaldwell, Robert William
dc.date.accessioned2012-10-26T16:26:55Z
dc.date.available2012-10-26T16:26:55Z
dc.date.issued2010en_US
dc.identifier.citationJ Cardiovasc Dis Res. 2010 Oct-Dec; 1(4):165-170en_US
dc.identifier.issn0976-2833en_US
dc.identifier.pmid21264179en_US
dc.identifier.doi10.4103/0975-3583.74258en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/626
dc.description.abstractEndothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
dc.rights© Journal of Cardiovascular Disease Researchen_US
dc.subjectInvited Reviewen_US
dc.titleThe role of RhoA/Rho kinase pathway in endothelial dysfunctionen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC3023892en_US
dc.contributor.corporatenameDepartment of Pharmacology and Toxicology
dc.contributor.corporatenameVascular Biology Center
refterms.dateFOA2019-04-10T00:21:13Z
html.description.abstractEndothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.


Files in this item

Thumbnail
Name:
JCardiovascDisRes14165-6852731 ...
Size:
462.0Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record