Authors
Yao, LinRomero, Maritza J.
Toque, Haroldo A.
Yang, Guang
Caldwell, Ruth B.
Caldwell, Robert William
Issue Date
2010
Metadata
Show full item recordAbstract
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.Citation
J Cardiovasc Dis Res. 2010 Oct-Dec; 1(4):165-170ae974a485f413a2113503eed53cd6c53
10.4103/0975-3583.74258