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dc.contributor.authorZhu, Haidong
dc.contributor.authorWang, Xiaoling
dc.contributor.authorGutin, Bernard
dc.contributor.authorDavis, Catherine L.
dc.contributor.authorKeeton, Daniel
dc.contributor.authorThomas, Jeffrey
dc.contributor.authorStallmann-Jorgensen, Inger
dc.contributor.authorMooken, Grace
dc.contributor.authorBundy, Vanessa
dc.contributor.authorSnieder, Harold
dc.contributor.authorVan Der Harst, Pim
dc.contributor.authorDong, Yanbin
dc.date.accessioned2023-12-12T15:30:02Z
dc.date.available2023-12-12T15:30:02Z
dc.date.issued2011-02
dc.identifier.citationZhu, H., Wang, X., Gutin, B., Davis, C. L., Keeton, D., Thomas, J., Stallmann-Jorgensen, I., Mooken, G., Bundy, V., Snieder, H., Van Der Harst, P., & Dong, Y. (2011). Leukocyte telomere length in healthy caucasian and african-american adolescents: Relationships with race, sex, adiposity, adipokines, and physical activity. Journal of Pediatrics, 158(2), 215-220. https://doi.org/10.1016/j.jpeds.2010.08.007en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624935
dc.description.abstractObjective: To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents. Study design: Leukocyte telomere length (T/S ratio) was assessed cross-sectionally in 667 adolescents (aged 14-18 years; 48% African-Americans; 51% girls) using a quantitative polymerase chain reaction method. Generalized estimating equations analyses were performed. Results: Telomere length was greater in the African-American adolescents than in the Caucasian adolescents (age- and sex-adjusted T/S ratio ± SE, 1.32 ± 0.01 vs 1.27 ± 0.01: P = .014) and greater in girls than in boys (age- and race-adjusted T/S ratio ± SE, 1.31 ± 0.01 vs 1.27 ± 0.01; P = .007). None of the adiposity or adipokine measures explained a significant proportion of the variance in telomere length. Vigorous physical activity was positively associated with telomere length (adjusted R2 = 0.019; P = .009) and accounted for 1.9% of the total variance only in girls. Conclusions: This study, conducted in a biracial adolescent cohort, demonstrated that (1) race and sex differences in telomere length have already emerged during adolescence; (2) adiposity and adipokines are not associated with telomere length at this age; and (3) the antiaging effect of vigorous physical activity may begin in youth, especially in girls.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.url10.1016/j.jpeds.2010.08.007en_US
dc.titleLeukocyte telomere length in healthy caucasian and african-american adolescents: Relationships with race, sex, adiposity, adipokines, and physical activityen_US
dc.typeAbstracten_US
dc.typeArticleen_US
dc.contributor.departmentGEORGIA PREVENTION INSTITUTEen_US
dc.identifier.journalJournal of Pediatricsen_US
dc.description.advisorCatherine Davis, MS.Phden_US


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