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dc.contributor.authorPollock, Norman K.
dc.contributor.authorBernard, Paul J.
dc.contributor.authorGutin, Bernard
dc.contributor.authorDavis, Catherine L.
dc.contributor.authorZhu, Haidong
dc.contributor.authorDong, Yanbin
dc.date.accessioned2023-12-12T15:22:53Z
dc.date.available2023-12-12T15:22:53Z
dc.date.issued2011-05
dc.identifier.citationPollock, N. K., Bernard, P. J., Gutin, B., Davis, C. L., Zhu, H., & Dong, Y. (2011). Adolescent obesity, bone mass, and cardiometabolic risk factors. Journal of Pediatrics, 158(5), 727-734. https://doi.org/10.1016/j.jpeds.2010.11.052en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624934
dc.description.abstractObjective: To compare bone mass between overweight adolescents with and without cardiometabolic risk factors (CMR). Associations of bone mass with CMR and adiposity were also determined. Study design: Adolescents (aged 14 to 18 years) who were overweight were classified as healthy (n = 55), having one CMR (1CMR; n = 46), or having two or more CMR (≥2CMR; n = 42). CMRs were measured with standard methods and defined according to pediatric definitions of metabolic syndrome. Total body bone mass, fat mass, and fat-free soft tissue mass were measured with dual-energy X-ray absorptiometry. Visceral adipose tissue and subcutaneous abdominal adipose tissue were assessed with magnetic resonance imaging. Results: After controlling for age, sex, race, height, and fat-free soft tissue mass, the healthy group had 5.4% and 6.3% greater bone mass than the 1CMR and ≥2CMR groups, respectively (both P values <.04). With multiple linear regression, adjusting for the same co-variates, visceral adipose tissue (β = -0.22), waist circumference (β = -0.23), homeostasis model assessment of insulin resistance (β = -0.23), and high-density lipoprotein cholesterol level (β = 0.22) were revealed to be associated with bone mass (all P values <.04). There was a trend toward a significant inverse association between bone mass and fasting glucose level (P = .056). No relations were found between bone mass and fat mass, subcutaneous abdominal adipose tissue, blood pressure, or triglyceride level. Conclusion: Being overweight with metabolic abnormalities, particularly insulin resistance, low high-density lipoprotein cholesterol level, and visceral adiposity, may adversely influence adolescent bone mass.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.url10.1016/j.jpeds.2010.11.052en_US
dc.titleAdolescent obesity, bone mass, and cardiometabolic risk factorsen_US
dc.typeAbstracten_US
dc.typeArticleen_US
dc.contributor.departmentGEORGIA PREVENTION INSTITUTEen_US
dc.identifier.journalJournal of Pediatricsen_US
dc.description.advisorCatherine Davis, MS.Phden_US


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