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dc.contributor.authorPollock, Norman K.
dc.contributor.authorBernard, Paul J.
dc.contributor.authorGower, Barbara A.
dc.contributor.authorGundberg, Caren M.
dc.contributor.authorWenger, Karl
dc.contributor.authorMisra, Sudipta
dc.contributor.authorBassali, Reda W.
dc.date.accessioned2023-12-12T15:11:42Z
dc.date.available2023-12-12T15:11:42Z
dc.date.issued2011-07-01
dc.identifier.citationPollock, N. K., Bernard, P. J., Gower, B. A., Gundberg, C. M., Wenger, K., Misra, S., Bassali, R. W., & Davis, C. L. (2011). Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with β-cell function. Journal of Clinical Endocrinology and Metabolism, 96(7), E1092-E1099. https://doi.org/10.1210/jc.2010-2731en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624932
dc.description.abstractContext: Although animal studies suggest that it is the uncarboxylated rather than carboxylated form of osteocalcin that affects glucose homeostasis, the human data are scant and equivocal. Objective: This study investigated associations of uncarboxylated and carboxylated forms of osteocalcin with insulin sensitivity and β-cell function in 140 overweight prepubertal children (43% female, 46% black, 84% obese) with normal glucose levels (n = 99) and prediabetes (n = 41). Methods: An oral glucose tolerance test was used to identify prediabetes and for measurement of insulin sensitivity (Matsuda index), β-cell function [oral glucose tolerance test derived insulinogenic index and disposition index (DIOGTT)] and uncarboxylated and carboxylated forms of osteocalcin. Visceral adipose tissue (VAT) was assessed using magnetic resonance imaging. Results: After controlling for age, sex and race, lower uncarboxylated osteocalcin concentrations, Matsuda index, insulinogenic index, and DIOGTT and higher VAT levels were found in the prediabetes vs. normal-glucose group (all P < 0.03). Carboxylated osteocalcin levels were not different between groups. Multiple linear regression adjusting for age, sex, race, and VAT revealed that uncarboxylated osteocalcin was associated with insulinogenic index and DIOGTT (β = 0.34, 0.36, respectively, both P < 0.04) in the prediabetes group but not the normal-glucose group. In both the normal-glucose and prediabetes groups, carboxylated osteocalcin was associated with insulin sensitivity (β = 0.26, 0.47, respectively, both P < 0.02). Conclusions: These data suggest that the lower uncarboxylated osteocalcin concentrations found in children with prediabetes may be associated with β-cell dysfunction. In addition, our findings between carboxylated osteocalcin and insulin sensitivity suggest that carboxylated osteocalcin plays a role in human glucose homeostasis.en_US
dc.language.isoen_USen_US
dc.publisherOxford Academicen_US
dc.relation.url10.1210/jc.2010-2731en_US
dc.titleLower Uncarboxylated Osteocalcin Concentrations in Children with Prediabetes Is Associated with β-Cell Functioen_US
dc.typeAbstracten_US
dc.typeArticleen_US
dc.contributor.departmentGEORGIA PREVENTION INSTITUTEen_US
dc.identifier.journalThe Journal of Clinical Endocrinology & Metabolismen_US
dc.description.advisorCatherine Davis, MS.Phden_US
refterms.dateFOA2023-12-12T15:11:44Z


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