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dc.contributor.authorPollock, Norman K
dc.contributor.authorBundy, Vanessa
dc.contributor.authorKanto, William
dc.contributor.authorDavis, Catherine L.
dc.contributor.authorBernard, Paul J.
dc.contributor.authorZhu, Haidong
dc.contributor.authorGutin, Bernard
dc.contributor.authorDong, Yanbin
dc.date.accessioned2023-12-06T17:21:45Z
dc.date.available2023-12-06T17:21:45Z
dc.date.issued2012-02-01
dc.identifier.citationPollock, N. K., Bundy, V., Kanto, W., Davis, C. L., Bernard, P. J., Zhu, H., Gutin, B., & Dong, Y. (2012). Greater fructose consumption is associated with cardiometabolic riskmarkers and visceral adiposity in adolescents. Journal of Nutrition, 142(2), 251-257. https://doi.org/10.3945/jn.111.150219en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624924
dc.description.abstractThough adolescents consume more fructose than any other age group, the relationship between fructose consumption and markers of cardiometabolic risk has not been established in this population. We determined associations of total fructose intake (free fructose plus one-half the intake of free sucrose) with cardiometabolic risk factors and type of adiposity in 559 adolescents aged 14-18 y. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, and C-reactive protein. Diet was assessed with 4-7 24-h recalls and physical activity (PA) was determined by accelerometry. Fat-free soft tissue (FFST) mass and fat mass were measured by DXA. The s.c. abdominal adipose tissue (SAAT) and visceral adipose tissue (VAT) were assessed using MRI. Multiple linear regression, adjusting for age, sex, race, Tanner stage, FFST mass, fat mass, PA, energy intake, fiber intake, and socioeconomic status, revealed that fructose intake was associated with VAT (β = 0.13; P = 0.03) but not SAAT (P = 0.15). Significant linear upward trends across tertiles of fructose intake were observed for systolic blood pressure, fasting glucose, HOMA-IR, and C-reactive protein after adjusting for the same covariates (all P-trend < 0.04). Conversely, significant linear downward trends across tertiles of fructose intake were observed for plasma HDL-cholesterol and adiponectin (both P-trend < 0.03). When SAAT was added as a covariate, these trends persisted (all P-trend < 0.05). However, when VAT was included as a covariate, it attenuated these trends (all P-trend < 0.05). In adolescents, higher fructose consumption is associated with multiple markers of cardiometabolic risk, but it appears that these relationships are mediated by visceral obesity.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.url10.3945/jn.111.150219en_US
dc.titleGreater fructose consumption is associated with cardiometabolic riskmarkers and visceral adiposity in adolescentsen_US
dc.typeAbstracten_US
dc.typeArticleen_US
dc.contributor.departmentGEORGIA PREVENTION INSTITUTEen_US
dc.identifier.journalJournal of Nutritionen_US
refterms.dateFOA2023-12-06T17:21:47Z


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