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dc.contributor.authorOtunuga, Olusegun Michael
dc.date.accessioned2023-12-06T16:29:58Z
dc.date.available2023-12-06T16:29:58Z
dc.date.issued2022-07
dc.identifier.citationOtunuga, O. M. (2022). Analysis of multi-strain infection of vaccinated and recovered population through epidemic model: Application to COVID-19: Analysis of multi-strain epidemic model. PloS one, 17(7 July), Article e0271446. https://doi.org/10.1371/journal.pone.0271446en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624920
dc.description.abstractIn this work, an innovative multi-strain SV EAIR epidemic model is developed for the study of the spread of a multi-strain infectious disease in a population infected by mutations of the disease. The population is assumed to be completely susceptible to n different variants of the disease, and those who are vaccinated and recovered from a specific strain k (k ≤ n) are immune to previous and present strains j = 1, 2, . . ., k, but can still be infected by newer emerging strains j = k + 1, k + 2, ..., n. The model is designed to simulate the emergence and dissemination of viral strains. All the equilibrium points of the system are calculated and the conditions for existence and global stability of these points are investigated and used to answer the question as to whether it is possible for the population to have an endemic with more than one strain. An interesting result that shows that a strain with a reproduction number greater than one can still die out on the long run if a newer emerging strain has a greater reproduction number is verified numerically. The effect of vaccines on the population is also analyzed and a bound for the herd immunity threshold is calculated. The validity of the work done is verified through numerical simulations by applying the proposed model and strategy to analyze the multi-strains of the COVID-19 virus, in particular, the Delta and the Omicron variants, in the United State.en_US
dc.language.isoen_USen_US
dc.relation.url10.1371/journal.pone.0271446en_US
dc.titleAnalysis of multi-strain infection of vaccinated and recovered population through epidemic model: Application to COVID-19: Analysis of multi-strain epidemic modelen_US
dc.typeAbstracten_US
dc.typeArticleen_US
dc.contributor.departmentAugusta Universityen_US
dc.identifier.journalPloS oneen_US
refterms.dateFOA2023-12-06T16:30:00Z


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