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dc.contributor.authorWijayasinghe, Yasanandana S.
dc.contributor.authorBhansali, Meenakshi P.
dc.contributor.authorBorkar, Maheshkumar R.
dc.contributor.authorChaturbhuj, Ganesh U.
dc.contributor.authorMuntean, Brian S.
dc.contributor.authorViola, Ronald E.
dc.contributor.authorBhansali, Pravin R.
dc.date.accessioned2023-11-28T16:21:28Z
dc.date.available2023-11-28T16:21:28Z
dc.date.issued2022-03-10
dc.identifier.citationWijayasinghe, Y. S., Bhansali, M. P., Borkar, M. R., Chaturbhuj, G. U., Muntean, B. S., Viola, R. E., & Bhansali, P. R. (2022). A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials. Journal of Medicinal Chemistry, 65(5), 3706-3728. https://doi.org/10.1021/acs.jmedchem.1c01737en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/624909
dc.description.abstractGlucose, the primary substrate for ATP synthesis, is catabolized during glycolysis to generate ATP and precursors for the synthesis of other vital biomolecules. Opportunistic viruses and cancer cells often hijack this metabolic machinery to obtain energy and components needed for their replication and proliferation. One way to halt such energy-dependent processes is by interfering with the glycolytic pathway. 2-Deoxy-d-glucose (2-DG) is a synthetic glucose analogue that can inhibit key enzymes in the glycolytic pathway. The efficacy of 2-DG has been reported across an array of diseases and disorders, thereby demonstrating its broad therapeutic potential. Recent approval of 2-DG in India as a therapeutic approach for the management of the COVID-19 pandemic has brought renewed attention to this molecule. The purpose of this perspective is to present updated therapeutic avenues as well as a variety of chemical synthetic strategies for this medically useful sugar derivative, 2-DG.en_US
dc.language.isoenen_US
dc.publisherACS Publicationsen_US
dc.relation.url10.1021/acs.jmedchem.1c01737en_US
dc.subjectMolecular Medicineen_US
dc.subjectDrug Discoveryen_US
dc.titleA Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentialsen_US
dc.title.alternative10.1021/acs.jmedchem.1c01737en_US
dc.typeAbstracten_US
dc.contributor.departmentAugusta Universityen_US
dc.identifier.journalJournal of Medicinal Chemistryen_US


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