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dc.contributor.authorDe Souza, Godfrey
dc.date.accessioned2023-08-03T18:11:06Z
dc.date.available2023-08-03T18:11:06Z
dc.date.issued2022-12
dc.identifier.urihttp://hdl.handle.net/10675.2/624710
dc.descriptionThe file you are attempting to access is restricted to Augusta University. Please login using your JagNet iD and password.en_US
dc.description.abstractFor many generations of scientific study, it was generally accepted that most genes/proteins during health are static, and only change expression during disease. However, since the 1990s, a subset of genes were identified that naturally change during the day; they increase and decrease naturally, in a pattern that mimics the day/light cycle otherwise referred to as the circadian rhythm. Further, the thinking was that some proteins and genes were so important that they could be counted on to be (there) expressed constitutively, so called housekeeping genes. A housekeeping gene is a gene that is thought to always remain active. However, this study focuses primarily on how glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may potentially exhibit a circadian rhythm and how that is affected when eliminating Bmal-1 (a circadian pathway gene). There is also information on how Per1, a circadian clock gene, is affected by the elimination of Bmal-1. In summary, the data supports the theory that GAPDH is showing oscillatory capabilities which were affected by manipulation of Bmal-1. The experiments also display that Per1 is affected by manipulation of Bmal-1 as well. If GAPDH exhibits a circadian rhythm, then what about the other housekeeping genes? These experiments open a new avenue of questions which may potentially revolutionize research.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.titleCharacterizations of Circadian Rhythms and Housekeeping Genes in the Mouse Hippocampusen_US
dc.typeThesisen_US
dc.contributor.departmentCell and Molecular Biologyen_US
dc.description.advisorRudic, Dan
dc.description.committeeRudic, Dan; Wiley, Faith; Curry-McCoy, Tiana


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