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dc.contributor.authorMiller, Colin George Lee, Jr.
dc.date.accessioned2023-08-03T18:11:05Z
dc.date.available2023-08-03T18:11:05Z
dc.date.issued2023-05
dc.identifier.urihttp://hdl.handle.net/10675.2/624703
dc.descriptionThe file you are attempting to access is restricted to Augusta University. Please login using your JagNet iD and password.en_US
dc.description.abstractSildenafil is a drug commonly used for the treatment of erectile dysfunction. It is known to have many beneficial effects, such as helping prevent heart failure. Many of these effects occur due to sildenafil working as a phosphodiesterase-5 (PDE5) inhibitor drug. PDE5 is an enzyme that controls blood flow and cell signaling. By inhibiting the PDE5 enzyme, muscles and blood vessels tend to relax, increasing blood flow. Recently, it has been discovered that PDE5 inhibitors can prevent colorectal cancer in animals, and recent evidence suggests that these drugs will also be effective in humans. A problem with repurposing contemporary PDE5i, such as sildenafil, for colon cancer prevention is the drug's side effects and drug-drug interactions, such as reacting with nitrates to further lower blood pressure or increase the risk of erectile dysfunction. In this project, we aim to create novel PDE5i drugs that eliminate these unwanted effects by keeping them in the colon, where they can work their magic, minimizing or avoiding leakage into the bloodstream. This project explores sildenafil alongside other PDE5 inhibitors designed to remain in the gastrointestinal (GI) tract. By modifying the structure of sildenafil, we aim to create novel drug candidates that localize in the colon, keeping its beneficial effects of increased blood flow. As a result, the onset of colon cancer in humans can theoretically be prevented.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.titleSildenafil Analog Designed as Localized PDES Inhibitors in the Gastrointestinal Tracten_US
dc.typeThesisen_US
dc.contributor.departmentChemistryen_US
dc.description.advisorMiao, Shaobin
dc.description.committeeMiao, Shaobin; Agee, Brian; Davis, Julia


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