• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Dental College of Georgia (DCG)
    • DCG Research and Table Clinic Day
    • DCG Research and Table Clinic Day 2020
    • View Item
    •   Home
    • Colleges & Programs
    • Dental College of Georgia (DCG)
    • DCG Research and Table Clinic Day
    • DCG Research and Table Clinic Day 2020
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    The Clinical Aspects of Hypophosphatasia

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Baker and Simpson_Abstract.pdf
    Size:
    156.5Kb
    Format:
    PDF
    Download
    Authors
    Baker, Abby
    Simpson, Sage
    Issue Date
    2020-02-13
    URI
    http://hdl.handle.net/10675.2/624355
    
    Metadata
    Show full item record
    Abstract
    OBJECTIVES: The purpose of this research is to educate the dental community on the effects of hypophosphatasia and the clinical manifestations it presents throughout the body and the oral cavity. METHODS: Hypophosphatasia is a rare inherited metabolic disorder that has a wide spectrum of disease presentation. Due to 300 types of ALP mutations, HPP has six different major forms: perinatal lethal, prenatal benign, infantile, childhood, adulthood, and odotohypophosphatasia. There are clinical signs presented throughout the body and the oral cavity. Premature exfoliation of primary dentition is the first clinical sign of hypophosphatasia in childhood. Two different studies were reviewed in order to compare similar symptoms of hypophosphatasia. RESULTS: In one case study there were 38 patients who reported similar symptoms. In 15 (39%) of the patients a history of fractures was present. In the same study 21 (55%) of the patients had recurring headaches, 4 (11%) of the patients experienced severe muscle weakness, 23 (61%) experienced recurring muscle pain, and 18 (47%) of the patients exhibited dental abnormalities. In another case study there were 9 patients that reported only dental signs of hypophosphatasia. Dental signs of HPP were shown in childhood in 8 (88%) of the patients. The premature loss of the primary dentition was shown in 7 (77%) of the patients, absent primary dentition in 1 (11%) of the patients, and delayed loss of primary teeth in 1 (11%) of the patients. CONCLUSIONS: Since hypophosphatasia is so rare, more studies are needed on the diagnosis, preventative methods, and treatments. The majority of HPP cases are diagnosed in adulthood which ensures the disorder could have been present during childhood and was overlooked. In order to diagnose the disorder promptly, there should be a thorough medical history and clinical signs must be evaluated. There is no cure or long term prognosis for the hypophosphatasia disorder.
    Affiliation
    Dental Hygiene
    Collections
    DCG Research and Table Clinic Day 2020

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.