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dc.contributor.authorGarner, Jamani
dc.date.accessioned2022-06-01T14:30:48Z
dc.date.available2022-06-01T14:30:48Z
dc.date.issued2022-05
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/624292
dc.descriptionRecord is embargoed until 06/01/2025en_US
dc.description.abstractA key goal in preclinical pain research is improving the translational value of findings by modeling pain states elicited in humans. Examining the expression and treatment of pain-related disruption of behavior represents one approach to improving the alignment between preclinical pain research and clinical settings. Past studies support the ability of the intermediate efficacy opioid, morphine, to restore pain-related depression of nesting in mice. In the present study, we aimed to investigate the effects of the low efficacy opioid, buprenorphine, and the high efficacy opioid, methadone, on lactic-acid induced depression of Nestlet shredding in male and female ICR mice. At the start of test sessions, 5 × 5 cm Nestlets were weighed and suspended from the wire lid of the home cages. Under control conditions, mice removed pieces of the suspended Nestlets to build nests. The results indicated that intraperitoneal injections of 0.18% lactic acid disrupted Nestlet shredding. Unlike morphine, both buprenorphine and methadone failed to restore acid-induced depression of shredding. In the absence of acid, both buprenorphine and methadone significantly depressed shredding. Our findings highlight the need for additional testing of these drugs across different pain procedures and noxious stimulus intensities to determine whether a balance can be achieved between their rate-decreasing and antinociceptive effects.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectnesting, pain, opioids, methadone, buprenorphine, pain-related depression of behavioren_US
dc.titleEXAMINING THE EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON PAIN - RELATED DEPRESSION OF NESTING IN MICEen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Psychological Sciencesen_US
dc.description.advisorMiller, Laurence
dc.description.majorPsychological Sciencesen_US
dc.description.committeeHoane, Michael
dc.description.committeePatton, Tadd
dc.description.degreeM.S.en_US
dc.embargoen
dc.description.embargo2025-06-01


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Copyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.
Except where otherwise noted, this item's license is described as Copyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.