• Login
    View Item 
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    T cells and NLRP3 Mediate High Fat Diet-Induced Increases in Blood Pressure and Adiposity in Female and Male Dahl Rats

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Ramirez_gru_1907E_10246.pdf
    Embargo:
    2032-12-31
    Size:
    7.594Mb
    Format:
    PDF
    Download
    Authors
    Ramirez, Lindsey
    Issue Date
    2022-05
    URI
    http://hdl.handle.net/10675.2/624284
    
    Metadata
    Show full item record
    Abstract
    Cardiovascular disease (CVD) is the leading cause of death worldwide in both sexes, with hypertension being an important modifiable factor. To increase the number of people with adequate blood pressure control, a better understanding of the mechanisms controlling the development of hypertension is necessary. Chronic consumption of a high fat diet (HFD) increases blood pressure and adiposity. Furthermore, clinical data suggest that women may be predisposed to worse cardiovascular health in instances of excess adiposity. Thus, these experiments were designed to test the central hypothesis that a HFD will increase blood pressure and adiposity more in females vs males. Sprague Dawley rats were resistant to HFD-induced increases in blood pressure or fat mass. Conversely, 10 weeks of HFD treatment increased blood pressure, fat mass, and adipose tissue weight in female and male Dahl Wild Type (WT) rats. This was accompanied by a pro-hypertensive T cell profile in both sexes. This finding pointed to a role for T cells in mediating the morbidity observed, T cell-deficient rats were utilized. T cell knock out (KO) blunted the HFD-induced hypertension in both sexes, but only the HFD-induced increase in adiposity in males. Due to the observed protective role of T cell KO, it was crucial to determine what could be activating T cells. NLRP3 is a pattern recognition receptor which activates T cells and adipogenesis, NLRP3 deficient rats were randomized to a Control (Ctrl) or HFD treatment. NLRP3 KO blunted the HFD-induced adiposity in both sexes. It is well known that free fatty acids (FFAs) can activate NLRP3, so a FFA panel was performed in Dahl WT animals. Females had a more pro-hypertensive FFA profile. The Dahl WT rat is a good model to use to study the loss of protection of females that are on a HFD. Additionally, these data demonstrate that T cells and NLRP3 are playing sex-specific roles to promote the HFD-induced increases in adiposity and blood pressure. Finding sex-specific mechanisms that mediate these morbidities will reduce the number of people that develop hypertension and subsequently, CVD, the number one killer of both men and women in the US.
    Affiliation
    Biomedical Sciences
    Collections
    Theses and Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.