Show simple item record

dc.contributor.authorKolhe, Ravindra
dc.contributor.authorSahajpal, Nikhil Shri
dc.contributor.authorVyavahare, Sagar
dc.contributor.authorDhanani, Akhilesh S.
dc.contributor.authorAdusumilli, Satish
dc.contributor.authorAnanth, Sudha
dc.contributor.authorMondal, Ashis K.
dc.contributor.authorPatterson, G. Taylor
dc.contributor.authorKumar, Sandeep
dc.contributor.authorRojiani, Amyn M.
dc.contributor.authorIsales, Carlos M.
dc.contributor.authorFulzele, Sadanand
dc.date.accessioned2022-03-09T15:00:32Z
dc.date.available2022-03-09T15:00:32Z
dc.date.issued2021-09-05
dc.identifier.doi10.3390/diagnostics11091622
dc.identifier.urihttp://hdl.handle.net/10675.2/624240
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is an infectious virus that causes coronavirus disease 2019 (COVID-19) transmitted mainly through droplets and aerosol affecting the respiratory tract and lungs. Little is known regarding why some individuals are more susceptible than others and develop severe symptoms. In this study, we analyzed the nasopharyngeal microbiota profile of aged patients with COVID-19 (asymptomatic vs. symptomatic) vs. healthy individuals. We examined the nasopharynx swab of 84 aged-matched patients, out of which 27 were negative asymptomatic (NegA), 30 were positive asymptomatic (PA), and 27 patients were positive symptomatic (PSY). Our analysis revealed the presence of abundant Cyanobacterial taxa at phylum level in PA (p-value = 0.0016) and PSY (p-value = 0.00038) patients along with an upward trend in the population of Litoricola, Amylibacter, Balneola, and Aeromonas at the genus level. Furthermore, to know the relationship between the nasal microbiota composition and severity of COVID-19, we compared PA and PSY groups. Our data show that the nasal microbiota of PSY patients was significantly enriched with the signatures of two bacterial taxa: Cutibacterium (p-value = 0.045) and Lentimonas (p-value = 0.007). Furthermore, we also found a significantly lower abundance of five bacterial taxa, namely: Prevotellaceae (p-value = 7 × 10−6 ), Luminiphilus (p-value = 0.027), Flectobacillus (p-value = 0.027), Comamonas (p-value = 0.048), and Jannaschia (p-value = 0.012) in PSY patients. The dysbiosis of the nasal microbiota in COVID-19 positive patients might have a role in contributing to the severity of COVID-19. The findings of our study show that there is a strong correlation between the composition of the nasal microbiota and COVID-19 severity. Further studies are needed to validate our finding in large-scale samples and to correlate immune response (cytokine Strome) and nasal microbiota to identify underlying mechanisms and develop therapeutic strategies against COVID-19.en_US
dc.description.sponsorshipThis publication is based upon work supported in part by the National Institutes of Health AG036675 (National Institute on Aging-AG036675 S.F, C.I,).en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectmicrobiota; nasopharyngeal profile in aged patients with COVID-19 infection and severityen_US
dc.titleAlteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19en_US
dc.typeArticleen_US
dc.contributor.departmentDepartment of Pathology; Department of Cellular Biology and Anatomy; Department of Orthopedics; Department of Medicine; Center for Healthy Agingen_US
dc.identifier.journalDiagnosticsen_US
refterms.dateFOA2022-03-09T15:00:33Z


Files in this item

Thumbnail
Name:
alteration_in_nasopharyngeal_m ...
Size:
2.244Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record